tipranavir [Ligand Id: 12685] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL222559 (Aptivus, Tipranavir, U-140690) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CAAX prenyl protease 1 homolog in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075286] [UniProtKB: Q80W54] | ||||||||
| ChEMBL | Inhibition of mouse ZMPSTE24 expressed n delta ste24 delta rce1 yeast | B | 5.92 | pIC50 | 1200 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 13432-13437 [PMID:17652517] |
| cathepsin D/Cathepsin D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2581] [GtoPdb: 2345] [UniProtKB: P07339] | ||||||||
| ChEMBL | Compound was tested for inhibition human Cathepsin D | B | 4.82 | pKi | 15000 | nM | Ki | J Med Chem (1996) 39: 4349-4353 [PMID:8893827] |
| cathepsin E/Cathepsin E in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3092] [GtoPdb: 2346] [UniProtKB: P14091] | ||||||||
| ChEMBL | Compound was tested for inhibition human Cathepsin E | B | 5.05 | pKi | 9000 | nM | Ki | J Med Chem (1996) 39: 4349-4353 [PMID:8893827] |
| Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL243] [UniProtKB: Q72874] | ||||||||
| ChEMBL | Compound was tested for inhibition of HIV protease triple mutant (Q7K/L33I/L63I) | B | 9 | pKi | <1 | nM | Ki | J Med Chem (1996) 39: 4349-4353 [PMID:8893827] |
| ChEMBL | Tested for inhibition of HIV protease | B | 7.52 | pIC50 | 30 | nM | IC50 | J Med Chem (1996) 39: 4349-4353 [PMID:8893827] |
| ChEMBL | Inhibition of HIV-1 protease in a cell culture assay using HIV-1 IIIB infected H9 cells. | F | 7.52 | pIC50 | 30 | nM | IC50 | J Med Chem (1998) 41: 3467-3476 [PMID:9719600] |
| pepsinogen A5/Pepsin A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3295] [GtoPdb: 2390] [UniProtKB: P0DJD9] | ||||||||
| ChEMBL | Inhibition of human pepsin | B | 5.7 | pKi | 2000 | nM | Ki | J Med Chem (1996) 39: 4349-4353 [PMID:8893827] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimicrobial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 48 hrs | F | 4.68 | pEC50 | 21000 | nM | EC50 | Antimicrob Agents Chemother (2010) 54: 1334-1337 [PMID:20028821] |
| ChEMBL | Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs | F | 4.7 | pEC50 | 20000 | nM | EC50 | Antimicrob Agents Chemother (2010) 54: 1334-1337 [PMID:20028821] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum harboring HFP-tagged Pfs16 protein after 48 hrs | F | 4.74 | pEC50 | 18000 | nM | EC50 | Antimicrob Agents Chemother (2010) 54: 1334-1337 [PMID:20028821] |
| ChEMBL | Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum D10 after 48 hrs | F | 4.92 | pEC50 | 12000 | nM | EC50 | Antimicrob Agents Chemother (2010) 54: 1334-1337 [PMID:20028821] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
