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cathepsin E

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Target not currently curated in GtoImmuPdb

Target id: 2346

Nomenclature: cathepsin E

Family: A1: Pepsin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 396 1q32.1 CTSE cathepsin E
Mouse - 397 1 57.14 cM Ctse cathepsin E
Rat - 398 13q13 Ctse cathepsin E
Previous and Unofficial Names Click here for help
CatE | CE
Database Links Click here for help
Specialist databases
MEROPS A01.010 (Hs)
Other databases
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.23.34

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 2 [PMID: 8410973] Small molecule or natural product Hs Inhibition 10.0 pKi 2
pKi 10.0 (Ki 1x10-10 M) [2]
compound 3 [PMID: 8410973] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 9.3 pKi 2
pKi 9.3 (Ki 5x10-10 M) [2]
grassystatin A Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 9.1 pIC50 1
pIC50 9.1 (IC50 8.86x10-10 M) [1]
Immuno Process Associations
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II IDA

References

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1. Kwan JC, Eksioglu EA, Liu C, Paul VJ, Luesch H. (2009) Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem, 52 (18): 5732-47. [PMID:19715320]

2. Rao CM, Scarborough PE, Kay J, Batley B, Rapundalo S, Klutchko S, Taylor MD, Lunney EA, Humblet CC, Dunn BM. (1993) Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J Med Chem, 36 (18): 2614-20. [PMID:8410973]

How to cite this page

A1: Pepsin: cathepsin E. Last modified on 29/07/2015. Accessed on 08/12/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2346.