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cathepsin E

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Target not currently curated in GtoImmuPdb

Target id: 2346

Nomenclature: cathepsin E

Family: A1: Pepsin

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 396 1q32.1 CTSE cathepsin E
Mouse - 397 1 57.14 cM Ctse cathepsin E
Rat - 398 13q13 Ctse cathepsin E
Previous and Unofficial Names Click here for help
CatE | CE
Database Links Click here for help
Specialist databases
MEROPS A01.010 (Hs)
Other databases
Alphafold P14091 (Hs), P70269 (Mm), P16228 (Rn)
BRENDA 3.4.23.34
CATH/Gene3D 2.40.70.10
ChEMBL Target CHEMBL3092 (Hs), CHEMBL1681627 (Mm)
Ensembl Gene ENSG00000196188 (Hs), ENSMUSG00000004552 (Mm), ENSRNOG00000006963 (Rn)
Entrez Gene 1510 (Hs), 13034 (Mm), 25424 (Rn)
Human Protein Atlas ENSG00000196188 (Hs)
KEGG Enzyme 3.4.23.34
KEGG Gene hsa:1510 (Hs), mmu:13034 (Mm), rno:25424 (Rn)
OMIM 116890 (Hs)
Pharos P14091 (Hs)
RefSeq Nucleotide NM_148964 (Hs), NM_001910 (Hs), NM_007799 (Mm), NM_012938 (Rn)
RefSeq Protein NP_001901 (Hs), NP_683865 (Hs), NP_031825 (Mm), NP_037070 (Rn)
UniProtKB P14091 (Hs), P70269 (Mm), P16228 (Rn)
Wikipedia CTSE (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.23.34

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 2 [PMID: 8410973] Small molecule or natural product Hs Inhibition 10.0 pKi 2
⤷ pKi 10.0 (Ki 1x10-10 M) [2]
compound 3 [PMID: 8410973] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 9.3 pKi 2
⤷ pKi 9.3 (Ki 5x10-10 M) [2]
grassystatin A Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 9.1 pIC50 1
⤷ pIC50 9.1 (IC50 8.86x10-10 M) [1]
Immuno Process Associations
Immuno Process:  Antigen presentation

References

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1. Kwan JC, Eksioglu EA, Liu C, Paul VJ, Luesch H. (2009) Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem, 52 (18): 5732-47. [PMID:19715320]

2. Rao CM, Scarborough PE, Kay J, Batley B, Rapundalo S, Klutchko S, Taylor MD, Lunney EA, Humblet CC, Dunn BM. (1993) Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J Med Chem, 36 (18): 2614-20. [PMID:8410973]

How to cite this page

A1: Pepsin: cathepsin E. Last modified on 29/07/2015. Accessed on 20/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2346.