ChEMBL ligand: CHEMBL273453 (Aldosterone, NSC-73856)
Androgen receptor/Androgen Receptor in Rat [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207] There should be some charts here, you may need to enable JavaScript!
Corticosteroid binding globulin in Human [ChEMBL: CHEMBL2421] [UniProtKB: P08185] There should be some charts here, you may need to enable JavaScript!
Mineralocorticoid receptor in Human [ChEMBL: CHEMBL1994] [GtoPdb: 626] [UniProtKB: P08235] Mineralocorticoid receptor in Rat [ChEMBL: CHEMBL3507] [GtoPdb: 626] [UniProtKB: P22199] There should be some charts here, you may need to enable JavaScript!
Testis-specific androgen-binding protein in Human [ChEMBL: CHEMBL3305] [UniProtKB: P04278] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
ChEMBL	Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)	B	4.37	pIC50	>42657.95	nM	IC50	J Med Chem (2005) 48: 5666-5674 [PMID:16134935]
Corticosteroid binding globulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2421] [UniProtKB: P08185]
ChEMBL	Binding affinity to human CBG receptor (corticosteroid-binding globulins)	B	6.28	pKi	524.81	nM	Ki	J Med Chem (2004) 47: 2732-2742 [PMID:15139751]
Mineralocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1994] [GtoPdb: 626] [UniProtKB: P08235]
ChEMBL	Binding affinity to MR (unknown origin)	B	9.3	pKd	0.5	nM	Kd	J Med Chem (2017) 60: 2629-2650 [PMID:28051871]
ChEMBL	Antagonist activity at mineralocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as inhibition of transactivation activity after 18 hrs by luciferase reporter gene assay	F	8.03	pIC50	9.27	nM	IC50	J Med Chem (2010) 53: 6947-6953 [PMID:20812681]
ChEMBL	Agonist activity at GAL4 DNA-binding domain fused MR (unknown origin) ligand binding domain expressed in UAS-bla H cells assessed as beta-lactamase transcriptional activation by FRET-based GeneBLAzer assay	B	9.52	pIC50	0.3	nM	IC50	Eur J Med Chem (2018) 157: 791-804 [PMID:30144697]
GtoPdb	-	-	10	pIC50	-	-	-	Eur J Pharmacol (1993) 247: 145-54 [PMID:8282004]; FEBS Lett (1999) 464: 9-13 [PMID:10611474]
ChEMBL	Agonist activity at mineralocorticoid receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luciferase reporter gene assay	B	8.42	pEC50	3.8	nM	EC50	J Nat Prod (2009) 72: 1944-1948 [PMID:19863083]
ChEMBL	Agonist activity at MR (unknown origin) by Alpha Screen assay	B	8.89	pEC50	1.3	nM	EC50	Medchemcomm (2019) 10: 1412-1419 [PMID:31673308]
ChEMBL	Agonist activity at human MR expressed in CHO-K1 cells by PathHunter assay	B	9.22	pEC50	0.6	nM	EC50	J Med Chem (2022) 65: 9974-10000 [PMID:35797110]
ChEMBL	Agonist activity at mineralocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity after 18 hrs by luciferase reporter gene assay	F	9.47	pEC50	0.34	nM	EC50	J Med Chem (2010) 53: 6947-6953 [PMID:20812681]
ChEMBL	Agonist activity at human MCR expressed in HEK293 cells by luciferase reporter gene assay	B	9.74	pEC50	0.18	nM	EC50	Bioorg Med Chem Lett (2014) 24: 5265-5267 [PMID:25305688]
Mineralocorticoid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3507] [GtoPdb: 626] [UniProtKB: P22199]
ChEMBL	Displacement of [3H]aldosterone from Sprague-Dawley rat MR by liquid scintillation counting	B	7.37	pIC50	43	nM	IC50	Bioorg Med Chem Lett (2011) 21: 1744-1747 [PMID:21349712]
ChEMBL	Displacement of [3H]Aldo from mineralocorticoid receptor in Sprague-Dawley rat kidney after 2 hrs by liquid scintillation counting	B	7.37	pIC50	43	nM	IC50	Bioorg Med Chem Lett (2011) 21: 6310-6313 [PMID:21944856]
Testis-specific androgen-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3305] [UniProtKB: P04278]
ChEMBL	Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin	B	5.32	pKd	4786.3	nM	Kd	J Med Chem (2008) 51: 2047-2056 [PMID:18330978]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]