ChEMBL ligand: CHEMBL1118 (Desvenlafaxine, D-veniz, Khedezla, Mdd-xr, Newven, O-desmethylvenlafaxine, ODV, Pristiq)
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140] There should be some charts here, you may need to enable JavaScript!
DAT/Dopamine transporter in Human [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] There should be some charts here, you may need to enable JavaScript!
NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] Norepinephrine transporter in Rat [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4] There should be some charts here, you may need to enable JavaScript!
SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] SERT/Serotonin transporter in Rat [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
ChEMBL	Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain	B	7.22	pIC50	60	nM	IC50	J Med Chem (1990) 33: 2899-2905 [PMID:1976813]
DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
ChEMBL	Displacement of [3H]WIN35428 from human DAT transfected in HEK293 cells after 3 hrs by Wallac counting analysis	B	6.07	pKi	>854	nM	Ki	ACS Med Chem Lett (2013) 4: 560-564 [PMID:24900709]
GtoPdb	-	-	6.07	pKi	>854	nM	Ki	ACS Med Chem Lett (2013) 4: 560-4 [PMID:24900709]
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
ChEMBL	Displacement of [3H]Nisoxetine from human NET transfected in HEK293 cells after 3 hrs by Wallac counting analysis	B	6.19	pKi	>650	nM	Ki	ACS Med Chem Lett (2013) 4: 560-564 [PMID:24900709]
GtoPdb	-	-	6.19	pKi	>650	nM	Ki	ACS Med Chem Lett (2013) 4: 560-4 [PMID:24900709]
ChEMBL	Displacement of [3H]Nisoxetine from human NET transfected in HEK293 cells after 3 hrs by Wallac counting analysis	B	5.82	pIC50	1500	nM	IC50	ACS Med Chem Lett (2013) 4: 560-564 [PMID:24900709]
ChEMBL	Inhibition of human NET expressed in CHO cells assessed as reduction of [3H]-NE re-uptake preincubated for 10 mins followed by [3H]-NE addition measured after 10 mins by liquid scintillation counting	B	6.27	pIC50	538	nM	IC50	J Med Chem (2018) 61: 2133-2165 [PMID:28731336]
Norepinephrine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4]
ChEMBL	Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes	F	5.94	pIC50	1160	nM	IC50	J Med Chem (1990) 33: 2899-2905 [PMID:1976813]
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
GtoPdb	-	-	7.82	pKi	15	nM	Ki	ACS Med Chem Lett (2013) 4: 560-4 [PMID:24900709]
ChEMBL	Displacement of [3H]citalopram from human SERT transfected in HEK293 cells after 3 hrs by Wallac counting analysis	B	7.82	pKi	15	nM	Ki	ACS Med Chem Lett (2013) 4: 560-564 [PMID:24900709]
ChEMBL	Inhibition of human SERT expressed in CHO cells assessed as reduction of [3H]-5-HT re-uptake preincubated for 10 mins followed by [3H]-5-HT addition measured after 10 mins by liquid scintillation counting	B	7.28	pIC50	53	nM	IC50	J Med Chem (2018) 61: 2133-2165 [PMID:28731336]
ChEMBL	Displacement of [3H]citalopram from human SERT transfected in HEK293 cells after 3 hrs by Wallac counting analysis	B	7.77	pIC50	17	nM	IC50	ACS Med Chem Lett (2013) 4: 560-564 [PMID:24900709]
SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652]
ChEMBL	Displacement of [3H]-citalopram from Sprague-Dawley rat brain SERT after 1 hr	B	6.49	pKi	>324	nM	Ki	ACS Med Chem Lett (2013) 4: 560-564 [PMID:24900709]
ChEMBL	Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes	F	6.74	pIC50	180	nM	IC50	J Med Chem (1990) 33: 2899-2905 [PMID:1976813]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]