silodosin   Click here for help

GtoPdb Ligand ID: 493

Synonyms: KMD-3213 | Rapaflo® | Silodyx®
Approved drug
silodosin is an approved drug (FDA (2008), EMA (2010))
Compound class: Synthetic organic
Comment: Silodosin an α1-adrenoceptor antagonist with selectivity for prostate adrenoceptors (mainly the α1A subtype).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 14
Topological polar surface area 97.05
Molecular weight 495.23
XLogP 3.66
No. Lipinski's rules broken 1
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Canonical SMILES OCCCN1CCc2c1c(cc(c2)CC(NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N
Isomeric SMILES OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N
InChI InChI=1S/C25H32F3N3O4/c1-17(30-8-12-34-21-5-2-3-6-22(21)35-16-25(26,27)28)13-18-14-19-7-10-31(9-4-11-32)23(19)20(15-18)24(29)33/h2-3,5-6,14-15,17,30,32H,4,7-13,16H2,1H3,(H2,29,33)/t17-/m1/s1
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2008), EMA (2010))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
8043 silodosin
Synonyms Click here for help
KMD-3213 | Rapaflo® | Silodyx®
Database Links Click here for help
Specialist databases
GPCRdb Ligand silodosin
Other databases
BindingDB Ligand 50160154
CAS Registry No. 160970-54-7 (source: Scifinder)
ChEMBL Ligand CHEMBL24778
DrugBank Ligand DB06207
DrugCentral Ligand 4151
GtoPdb PubChem SID 135650458
PubChem CID 5312125
Search Google for chemical match using the InChIKey PNCPYILNMDWPEY-QGZVFWFLSA-N
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UniChem Compound Search for chemical match using the InChIKey PNCPYILNMDWPEY-QGZVFWFLSA-N
UniChem Connectivity Search for chemical match using the InChIKey PNCPYILNMDWPEY-QGZVFWFLSA-N
Wikipedia Silodosin

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Silodosin (links to external site)
Cat. No. 6663