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ChEMBL ligand: CHEMBL3237547 (ASTX-727 COMPONENT CEDAZURIDINE, ASTX727 COMPONENT CEDAZURIDINE, Cedazuridine, E-7727, E7727) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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cytidine deaminase/Cytidine deaminase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4502] [GtoPdb: 3133] [UniProtKB: P32320] | ||||||||
ChEMBL | Inhibition of human recombinant cytidine deaminase assessed as cytidine to uridine formation | B | 6.4 | pIC50 | 400 | nM | IC50 | J Med Chem (2014) 57: 2582-2588 [PMID:24520856] |
GtoPdb | Inhibition of recombinant hCDA, assessed as decrease in cytidine to uridine formation. | - | 6.4 | pIC50 | 400 | nM | IC50 | J Med Chem (2014) 57: 2582-8 [PMID:24520856] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]