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cytidine deaminase

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Target not currently curated in GtoImmuPdb

Target id: 3133

Nomenclature: cytidine deaminase

Family: Pyrimidine salvage

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 146 1p36.12 CDA cytidine deaminase
Previous and Unofficial Names Click here for help
cytidine aminohydrolase | cytosine nucleoside deaminase
Database Links Click here for help
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ChEMBL Target
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Enzyme Reaction Click here for help
EC Number: 3.5.4.5 cytidine + H+ + H2O = NH4+ + uridine

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Inhibitors
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Ligand Sp. Action Value Parameter Reference
cedazuridine Small molecule or natural product Hs Inhibition 6.4 pIC50 1
pIC50 6.4 (IC50 4x10-7 M) [1]
Description: Inhibition of recombinant hCDA, assessed as decrease in cytidine to uridine formation.
Biologically Significant Variant Comments
Mutations in the CDA gene are associated with decreased sensitivity to the cytosine nucleoside analogue chemotherapy drug cytarabine (cytosine arabinoside, Ara C).
General Comments
Cytidine deaminase (CDA) is an enzyme of the pyrimidine salvage pathway (a subdivision of nucleotide salvage). Salvage returns bases and nucleosides that are formed during degradation of RNA and DNA to the biosynthesis and interconversion pathways. CDA is a homotetrameric enzyme that catalyses the irreversible hydrolytic deamination of cytidine->uridine and deoxycytidine->deoxyuridine. This enzyme is the molecular target of the synthetic nucleoside analogue pharmacoenhancer cedazuridine.

References

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1. Ferraris D, Duvall B, Delahanty G, Mistry B, Alt J, Rojas C, Rowbottom C, Sanders K, Schuck E, Huang KC et al.. (2014) Design, synthesis, and pharmacological evaluation of fluorinated tetrahydrouridine derivatives as inhibitors of cytidine deaminase. J. Med. Chem., 57 (6): 2582-8. [PMID:24520856]

How to cite this page

Pyrimidine salvage: cytidine deaminase. Last modified on 08/07/2020. Accessed on 21/10/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3133.