Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	146	1p36.12	CDA	cytidine deaminase

Previous and Unofficial Names

cytidine aminohydrolase | cytosine nucleoside deaminase

Database Links
Alphafold	P32320 (Hs)
BRENDA	3.5.4.5
ChEMBL Target	CHEMBL4502 (Hs)
Ensembl Gene	ENSG00000158825 (Hs)
Entrez Gene	978 (Hs)
Human Protein Atlas	ENSG00000158825 (Hs)
KEGG Enzyme	3.5.4.5
KEGG Gene	hsa:978 (Hs)
OMIM	23920 (Hs)
Pharos	P32320 (Hs)
RefSeq Nucleotide	NM_001785 (Hs)
RefSeq Protein	NP_001776 (Hs)
UniProtKB	P32320 (Hs)
Wikipedia	CDA (Hs)

Enzyme Reaction
EC Number: 3.5.4.5 cytidine + H+ + H2O = NH4+ + uridine

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Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference cedazuridine Hs Inhibition 6.4 pIC50 1 ⤷ pIC50 6.4 (IC50 4x10-7 M) [1] Description: Inhibition of recombinant hCDA, assessed as decrease in cytidine to uridine formation.

Biologically Significant Variant Comments

Mutations in the CDA gene are associated with decreased sensitivity to the cytosine nucleoside analogue chemotherapy drug cytarabine (cytosine arabinoside, Ara C).

General Comments

Cytidine deaminase (CDA) is an enzyme of the pyrimidine salvage pathway (a subdivision of nucleotide salvage). Salvage returns bases and nucleosides that are formed during degradation of RNA and DNA to the biosynthesis and interconversion pathways. CDA is a homotetrameric enzyme that catalyses the irreversible hydrolytic deamination of cytidine->uridine and deoxycytidine->deoxyuridine. This enzyme is the molecular target of the synthetic nucleoside analogue pharmacoenhancer cedazuridine.