deoxycorticosterone [Ligand Id: 2871] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1498 (Desoxycorticosterone)
  • Corticosteroid binding globulin in Human [ChEMBL: CHEMBL2421] [UniProtKB: P08185]
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  • Organic cation transporter 2/Solute carrier family 22 member 2 in Rat [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2]
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  • Organic cation transporter 3/Solute carrier family 22 member 3 in Rat [ChEMBL: CHEMBL1770033] [GtoPdb: 1021] [UniProtKB: O88446]
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  • Testis-specific androgen-binding protein in Human [ChEMBL: CHEMBL3305] [UniProtKB: P04278]
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  • Glucocorticoid receptor in Human [GtoPdb: 625] [UniProtKB: P04150]
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  • Mineralocorticoid receptor in Human [GtoPdb: 626] [UniProtKB: P08235]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Corticosteroid binding globulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2421] [UniProtKB: P08185]
ChEMBL In silico binding affinity to human corticosteriod binding globulin B 6.65 pKd 6.65 - -Log Kdiss J. Med. Chem. (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL Binding affinity to human CBG receptor (corticosteroid-binding globulins) B 7.65 pKi 22.39 nM Ki J. Med. Chem. (2004) 47: 2732-2742 [PMID:15139751]
Organic cation transporter 2/Solute carrier family 22 member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2]
ChEMBL TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM) in OCT2-expressing HRPE cells F 5.72 pIC50 1900 nM IC50 J. Biol. Chem. (1998) 273: 32776-32786 [PMID:9830022]
Organic cation transporter 3/Solute carrier family 22 member 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770033] [GtoPdb: 1021] [UniProtKB: O88446]
ChEMBL TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM) in OCT3-expressing HRPE cells F 5.08 pIC50 8400 nM IC50 J. Biol. Chem. (1998) 273: 32776-32786 [PMID:9830022]
Testis-specific androgen-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3305] [UniProtKB: P04278]
ChEMBL Binding affinity towards human testosterone binding globulin. B 6.38 pKd 6.38 - -Log Kdiss J. Med. Chem. (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin B 7.38 pKd 41.69 nM Kd J. Med. Chem. (2008) 51: 2047-2056 [PMID:18330978]
Glucocorticoid receptor in Human [GtoPdb: 625] [UniProtKB: P04150]
GtoPdb - - 7.2 pIC50 - - - Eur. J. Pharmacol. (1993) 247: 145-54 [PMID:8282004];
J. Biol. Chem. (2000) 275: 19041-9 [PMID:10747884]
Mineralocorticoid receptor in Human [GtoPdb: 626] [UniProtKB: P08235]
GtoPdb - - 11 pIC50 - - - Eur. J. Pharmacol. (1993) 247: 145-54 [PMID:8282004]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]