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ChEMBL ligand: CHEMBL77395 (CP-226269) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
ChEMBL | Binding affinity towards human Dopamine receptor D2 | B | 6.92 | pKi | 120 | nM | Ki | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
ChEMBL | In vitro effective concentration tested on HEK293 cells co-transfected with ferret Dopamine receptor D2 using FLIPR assay | B | 6.28 | pEC50 | 527 | nM | EC50 | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
ChEMBL | In vitro effective concentration tested on HEK293 cells co-transfected with rat Dopamine receptor D2 using FLIPR assay | B | 7.26 | pEC50 | 55 | nM | EC50 | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
ChEMBL | Binding affinity towards human Dopamine receptor D3 | B | 6.25 | pKi | 560 | nM | Ki | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
ChEMBL | Binding affinity towards human D4.4 receptor | B | 8.44 | pKi | 3.6 | nM | Ki | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
ChEMBL | Effective concentration against human Dopamine receptor D4 | B | 7.49 | pEC50 | 32 | nM | EC50 | J Med Chem (2004) 47: 2348-2355 [PMID:15084133] |
ChEMBL | In vitro effective concentration tested on HEK293 cells co-transfected with human Dopamine receptor D4 using FLIPR assay | B | 7.49 | pEC50 | 32 | nM | EC50 | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
D4 receptor/Dopamine D4 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3361] [GtoPdb: 217] [UniProtKB: P30729] | ||||||||
GtoPdb | - | - | 9.4 | pKi | - | - | - | Mol Pharmacol (2004) 66: 1491-9 [PMID:15448188] |
ChEMBL | In vitro effective concentration tested on HEK293 cells co-transfected with rat Dopamine receptor D4 using FLIPR assay | B | 7.44 | pEC50 | 36 | nM | EC50 | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
ChEMBL | In vitro effective concentration tested on HEK293 cells co-transfected with ferret Dopamine receptor D4 using FLIPR assay | B | 7.66 | pEC50 | 22 | nM | EC50 | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
ChEMBL | Binding affinity towards human Opioid receptor kappa 1 | B | 6.52 | pKi | 300 | nM | Ki | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
ChEMBL | Binding affinity towards human 5-hydroxytryptamine 1A receptor | B | 6.7 | pKi | 200 | nM | Ki | J Med Chem (2004) 47: 3853-3864 [PMID:15239663] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]