A-119637 [Ligand Id: 490] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL268758 (A-119637) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] | ||||||||
| ChEMBL | Binding affinity for human Alpha-1A adrenergic receptor | B | 8.58 | pKi | 2.63 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| ChEMBL | Binding constant measured against Alpha-1A adrenergic receptor in human prostate; ++:moderately active | B | 8.59 | pKi | 2.6 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 657-664 [PMID:15664832] |
| GtoPdb | - | - | 8.6 | pKi | - | - | - | Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357] |
| Alpha-1a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4892] [UniProtKB: P18130] | ||||||||
| ChEMBL | Binding affinity towards bovine Alpha-1A adrenergic receptor | B | 9.56 | pKi | 0.27 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140] | ||||||||
| ChEMBL | In vitro functional activity at Alpha-1A adrenergic receptor in rat vas deferens | B | 8.07 | pKd | 8.51 | nM | Kd | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| GtoPdb | - | - | 8.6 | pKi | - | - | - | Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357] |
| ChEMBL | Binding affinity towards rat Alpha-1A adrenergic receptor | B | 8.61 | pKi | 2.43 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368] | ||||||||
| GtoPdb | - | - | 8.3 | pKi | - | - | - | Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357] |
| ChEMBL | Binding affinity towards human Alpha-1B adrenergic receptor | B | 8.33 | pKi | 4.66 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823] | ||||||||
| ChEMBL | In vitro functional activity at Alpha-1B adrenergic receptor in rat spleen | F | 8.69 | pKd | 2.04 | nM | Kd | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100] | ||||||||
| ChEMBL | Binding affinity towards human Alpha-1D adrenergic receptor | B | 9.6 | pKi | 0.25 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| GtoPdb | - | - | 9.6 | pKi | - | - | - | Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357] |
| α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944] | ||||||||
| ChEMBL | In vitro functional activity at Alpha-1D adrenergic receptor in rat aorta | B | 10.6 | pKd | 0.03 | nM | Kd | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| ChEMBL | Binding affinity towards rat Alpha-1D adrenergic receptor | B | 9.67 | pKi | 0.21 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| GtoPdb | - | - | 9.7 | pKi | - | - | - | Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357] |
| α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913] | ||||||||
| ChEMBL | Ancillary Binding affinity towards cloned human Alpha-2A adrenergic receptor | B | 7.11 | pKi | 77.8 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| α2B-adrenoceptor/Alpha-2b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL266] [GtoPdb: 26] [UniProtKB: P19328] | ||||||||
| ChEMBL | Ancillary Binding affinity towards rat alpha-2B receptor | B | 7.15 | pKi | 71 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825] | ||||||||
| ChEMBL | Ancillary Binding affinity to cloned human Alpha-2C adrenergic receptor | B | 7.13 | pKi | 74.7 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901] | ||||||||
| ChEMBL | Ancillary Binding affinity to rat Dopamine receptor D1 | B | 5.22 | pKi | 6090 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
| D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
| ChEMBL | Ancillary Binding affinity towards rat Dopamine receptor D2 | B | 7.3 | pKi | 50 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
