kanamycin [Ligand Id: 12132] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1384 (Kanamicina, Kanamycin, Kanamycine, Kanamycins)
  • 3-oxoacyl-[acyl-carrier-protein] synthase 3 in Escherichia coli [ChEMBL: CHEMBL4914] [UniProtKB: P0A6R0]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
3-oxoacyl-[acyl-carrier-protein] synthase 3 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4914] [UniProtKB: P0A6R0]
ChEMBL Inhibition of Escherichia coli FabH B 5.17 pIC50 6800 nM IC50 Bioorg Med Chem Lett (2014) 24: 2579-2583 [PMID:25318998]
Cx43/Gap junction alpha-1 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4680024] [GtoPdb: 728] [UniProtKB: P17302]
ChEMBL Inhibition of human Cx43 expressed in Escherichia coli LB2003 cells in medium containing 8 mM K+ and 10 uM IPTG by measuring cell growth after 18 hrs by plate reader B 4.32 pIC50 48000 nM IC50 Eur J Med Chem (2020) 203: 112602-112602 [PMID:32679454]
Cx26/Gap junction beta-2 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295738] [GtoPdb: 716] [UniProtKB: P29033]
ChEMBL Inhibition of human Cx26 expressed in Escherichia coli LB2003 cells in medium containing 4 mM K+ and 500 uM IPTG by measuring cell growth after 18 hrs by plate reader B 4.94 pIC50 11500 nM IC50 Eur J Med Chem (2020) 203: 112602-112602 [PMID:32679454]
ChEMBL Inhibition of recombinant human Cx26 expressed in Escherichia coli LB2003 assessed as reduction in cell growth measured after 18 hrs B 5.03 pIC50 9400 nM IC50 ACS Med Chem Lett (2018) 9: 697-701 [PMID:30034603]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]