enalapril [Ligand Id: 6322] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL578 (Lexxel, Vaseretic, Enalapril, Vasotec, C09AA02)
  • Angiotensin-converting enzyme in Human [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821]
  • Angiotensin-converting enzyme in Rabbit [ChEMBL: CHEMBL4074] [UniProtKB: P12822]
  • Angiotensin-converting enzyme in Rat [ChEMBL: CHEMBL2625] [GtoPdb: 1613] [UniProtKB: P47820]
  • This target only has 0 pki data point
  • 0
1 CHEMBL578_lig_chart_1 Angiotensin-converting enzyme HumanRabbitRat
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821]
GtoPdb - - 4.3 pIC50 50000 nM IC50 J Cardiovasc Pharmacol (1994) 23 Suppl 4: S11-5 [PMID:7527095]
ChEMBL Compound tested in vitro for inhibition of Angiotensin I converting enzyme B 5.9 pIC50 1273 nM IC50 J. Med. Chem. (1989) 32: 1600-1606 [PMID:2544729]
ChEMBL Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venom B 5.92 pIC50 1200 nM IC50 J. Med. Chem. (2002) 45: 5609-5616 [PMID:12477342]
ChEMBL In vitro inhibition of Angiotensin I converting enzyme in Hog plasma B 5.92 pIC50 1200 nM IC50 J. Med. Chem. (1990) 33: 1606-1615 [PMID:2160536]
ChEMBL Compound was tested for its inhibitory potency against Angiotensin I converting enzyme B 6.85 pIC50 140 nM IC50 J. Med. Chem. (1991) 34: 511-517 [PMID:1995872]
ChEMBL In vitro inhibitory activity against Angiotensin I converting enzyme from unpurified guinea pig serum B 6.85 pIC50 140 nM IC50 J. Med. Chem. (1985) 28: 1291-1295 [PMID:2993618]
ChEMBL Inhibition of guinea pig angiotensin I converting enzyme B 6.85 pIC50 140 nM IC50 J. Med. Chem. (1986) 29: 1953-1961 [PMID:3020249]
ChEMBL In vitro inhibitory activity against Angiotensin I converting enzyme B 8.35 pIC50 4.5 nM IC50 J. Med. Chem. (1985) 28: 1603-1606 [PMID:2999394]
ChEMBL Inhibitory activity against angiotensin I converting enzyme (ACE) B 8.35 pIC50 4.5 nM IC50 J. Med. Chem. (2000) 43: 305-341 [PMID:10669559]
ChEMBL In vitro inhibition against angiotensin converting enzyme (ACE) B 8.92 pIC50 1.2 nM IC50 Bioorg. Med. Chem. Lett. (1994) 4: 2673-2676
Angiotensin-converting enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4074] [UniProtKB: P12822]
ChEMBL In vitro inhibition of Angiotensin I converting enzyme activity in rabbit lung B 5.1 pIC50 8000 nM IC50 J. Med. Chem. (1986) 29: 784-796 [PMID:3009814]
ChEMBL In vitro inhibitory activity against rabbit lung Angiotensin I converting enzyme at pH 8.3 B 5.1 pIC50 8000 nM IC50 J. Med. Chem. (1985) 28: 57-66 [PMID:2981324]
ChEMBL DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) B 5.48 pIC50 3330 nM IC50 DrugMatrix in vitro pharmacology data
ChEMBL In vitro inhibition of Angiotensin I converting enzyme in rabbit lung B 6.1 pIC50 800 nM IC50 J. Med. Chem. (1990) 33: 1606-1615 [PMID:2160536]
ChEMBL Inhibition of rabbit lung ACE assessed as hippuryl-histidyl-leucine hydrolysis after 30 mins by colorimetric method B 6.91 pIC50 123 nM IC50 Bioorg. Med. Chem. (2015) 23: 3526-3533 [PMID:25922179]
ChEMBL Tested for 50% inhibition of Angiotensin converting enzyme(ACE) obtained from rabbit lung (in vitro) B 8.7 pIC50 2 nM IC50 J. Med. Chem. (1994) 37: 1823-1832 [PMID:8021921]
Angiotensin-converting enzyme in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2625] [GtoPdb: 1613] [UniProtKB: P47820]
ChEMBL Inhibition of rat Angiotensin I converting enzyme (ACE), using Hip-Gly-Gly as synthetic substrate. B 6.85 pIC50 140 nM IC50 J. Med. Chem. (1987) 30: 992-998 [PMID:3035180]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]