pibrentasvir   Click here for help

GtoPdb Ligand ID: 11268

Synonyms: ABT-530 | ABT530 | Mavyret® (glecaprevir + pibrentasvir)
Approved drug
pibrentasvir is an approved drug (EMA & FDA (2017))
Compound class: Synthetic organic
Comment: Pibrentasvir is an oral, direct-acting inhibitor of hepatitis C virus (HCV) non-structural protein 5A (NS5A) replication complex. It targets viral RNA replication and viron assembly.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 16
Hydrogen bond donors 4
Rotatable bonds 21
Topological polar surface area 199.58
Molecular weight 1112.49
XLogP 8.2
No. Lipinski's rules broken 3
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Canonical SMILES COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1[nH]c2c(n1)cc(c(c2)[C@H]1CC[C@@H](N1c1cc(F)c(c(c1)F)N1CCC(CC1)c1ccc(cc1)F)c1cc2[nH]c(nc2cc1F)[C@@H]1CCCN1C(=O)[C@H]([C@H](OC)C)NC(=O)OC)F)[C@H](OC)C
Isomeric SMILES COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1[nH]c2c(n1)cc(c(c2)[C@H]1CC[C@@H](N1c1cc(F)c(c(c1)F)N1CCC(CC1)c1ccc(cc1)F)c1cc2[nH]c(nc2cc1F)[C@@H]1CCCN1C(=O)[C@H]([C@H](OC)C)NC(=O)OC)F)[C@H](OC)C
InChI InChI=1S/C57H65F5N10O8/c1-29(77-3)49(67-56(75)79-5)54(73)70-19-7-9-47(70)52-63-41-25-35(37(59)27-43(41)65-52)45-15-16-46(72(45)34-23-39(61)51(40(62)24-34)69-21-17-32(18-22-69)31-11-13-33(58)14-12-31)36-26-42-44(28-38(36)60)66-53(64-42)48-10-8-20-71(48)55(74)50(30(2)78-4)68-57(76)80-6/h11-14,23-30,32,45-50H,7-10,15-22H2,1-6H3,(H,63,65)(H,64,66)(H,67,75)(H,68,76)/t29-,30-,45-,46-,47+,48+,49+,50+/m1/s1
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (EMA & FDA (2017))
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
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International Nonproprietary Names Click here for help
INN number INN
10260 pibrentasvir
Synonyms Click here for help
ABT-530 | ABT530 | Mavyret® (glecaprevir + pibrentasvir)
Database Links Click here for help
CAS Registry No. 1353900-92-1 (source: PubChem)
ChEMBL Ligand CHEMBL3545123
DrugBank Ligand DB13878
DrugCentral Ligand 5244
GtoPdb PubChem SID 434321703
PubChem CID 58031952
Search Google for chemical match using the InChIKey VJYSBPDEJWLKKJ-NLIMODCCSA-N
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UniChem Compound Search for chemical match using the InChIKey VJYSBPDEJWLKKJ-NLIMODCCSA-N
UniChem Connectivity Search for chemical match using the InChIKey VJYSBPDEJWLKKJ-NLIMODCCSA-N