ChEMBL ligand: CHEMBL512504 (A-769662)
protein kinase AMP-activated catalytic subunit alpha 1/AMP-activated protein kinase, alpha-1 subunit in Rat [ChEMBL: CHEMBL4533] [GtoPdb: 1541] [UniProtKB: P54645] There should be some charts here, you may need to enable JavaScript!
protein kinase AMP-activated non-catalytic subunit beta 2/protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 2/protein kinase AMP-activated catalytic subunit alpha 1/protein kinase AMP-activated non-catalytic subunit gamma 3/protein kinase AMP-activated non-catalytic subunit gamma 2/protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase, AMPK in Human [ChEMBL: CHEMBL2096907] [GtoPdb: 1544, 1545, 1542, 1541, 1547, 1546, 1543] [UniProtKB: O43741, P54619, P54646, Q13131, Q9UGI9, Q9UGJ0, Q9Y478] There should be some charts here, you may need to enable JavaScript!
protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 1/protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 in Human [ChEMBL: CHEMBL2111345] [GtoPdb: 1545, 1541, 1543] [UniProtKB: P54619, Q13131, Q9Y478] There should be some charts here, you may need to enable JavaScript!
protein kinase AMP-activated non-catalytic subunit beta 2/protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 1/AMPK alpha1/beta2/gamma1 in Human [ChEMBL: CHEMBL3038453] [GtoPdb: 1544, 1545, 1541] [UniProtKB: O43741, P54619, Q13131] There should be some charts here, you may need to enable JavaScript!
protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 2/protein kinase AMP-activated non-catalytic subunit beta 1/AMPK alpha2/beta1/gamma1 in Human [ChEMBL: CHEMBL3038455] [GtoPdb: 1545, 1542, 1543] [UniProtKB: P54619, P54646, Q9Y478] There should be some charts here, you may need to enable JavaScript!
AMP kinase in Human [GtoPdb: 1540] AMP kinase in Rat [GtoPdb: 1540] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
protein kinase AMP-activated catalytic subunit alpha 1/AMP-activated protein kinase, alpha-1 subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4533] [GtoPdb: 1541] [UniProtKB: P54645]
ChEMBL	Activation of rat AMPK-alpha-1-alpha-2beta-1-gamma-1 kinase	B	6.94	pEC50	116	nM	EC50	J. Biol. Chem. (2007) 282: 32549-32560 [PMID:17855357]
protein kinase AMP-activated non-catalytic subunit beta 2/protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 2/protein kinase AMP-activated catalytic subunit alpha 1/protein kinase AMP-activated non-catalytic subunit gamma 3/protein kinase AMP-activated non-catalytic subunit gamma 2/protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase, AMPK in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2096907] [GtoPdb: 1544, 1545, 1542, 1541, 1547, 1546, 1543] [UniProtKB: O43741, P54619, P54646, Q13131, Q9UGI9, Q9UGJ0, Q9Y478]
ChEMBL	Activation of AMPK (unknown origin)	B	6.1	pEC50	800	nM	EC50	J Med Chem (2018) 61: 4656-4687 [PMID:29211480]
ChEMBL	Activation of AMPK (unknown origin) by luminescence assay	B	6.24	pEC50	576	nM	EC50	Bioorg. Med. Chem. Lett. (2015) 25: 5237-5242 [PMID:26471090]
protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 1/protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111345] [GtoPdb: 1545, 1541, 1543] [UniProtKB: P54619, Q13131, Q9Y478]
ChEMBL	Binding affinity to human recombinant N-terminal AVI-tagged phosphorylated AMPK alpha1beta1gamma1 expressed in Escherichia coli BL21 cells after 1 to 10 mins by biolayer interferometry	B	6.29	pKd	510	nM	Kd	J. Med. Chem. (2016) 59: 2879-2893 [PMID:26510622]
ChEMBL	Binding affinity for full length human N-terminal His/BAP-tagged AMPK alpha1/beta1/gamma1 expressed in Escherichia coli BL21-CodonPlus by surface plasmon resonance method	B	6.31	pKd	487	nM	Kd	Bioorg Med Chem Lett (2016) 26: 5139-5148 [PMID:27727125]
ChEMBL	Activation of human AMPK alpha1/beta1/gamma1 expressed in baculovirus/Sf9 cells using SAMS peptide as substrate incubated for 15 mins by in presence of 33P-ATP by liquid scintillation counting method	B	6.1	pEC50	800	nM	EC50	Bioorg Med Chem Lett (2019) 29: 2443-2447 [PMID:31358465]
protein kinase AMP-activated non-catalytic subunit beta 2/protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 1/AMPK alpha1/beta2/gamma1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038453] [GtoPdb: 1544, 1545, 1541] [UniProtKB: O43741, P54619, Q13131]
ChEMBL	Binding affinity to human recombinant N-terminal AVI-tagged phosphorylated AMPK alpha1beta2gamma1 expressed in Escherichia coli BL21 cells after 1 to 10 mins by biolayer interferometry	B	4.84	pKd	14500	nM	Kd	J. Med. Chem. (2016) 59: 2879-2893 [PMID:26510622]
protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 2/protein kinase AMP-activated non-catalytic subunit beta 1/AMPK alpha2/beta1/gamma1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038455] [GtoPdb: 1545, 1542, 1543] [UniProtKB: P54619, P54646, Q9Y478]
ChEMBL	Activation of human AMPK alpha2/beta1/gamma1 expressed in Escherichia coli BL21	B	6.41	pEC50	390	nM	EC50	J Med Chem (2018) 61: 6421-6467 [PMID:29620890]
AMP kinase in Human [GtoPdb: 1540]
GtoPdb	Activation of AMPK partially purified from HEK cells.	-	5.96	pEC50	1100	nM	EC50	Cell Metab (2006) 3: 403-16 [PMID:16753576]
AMP kinase in Rat [GtoPdb: 1540]
GtoPdb	Activation of baculovirus expressed α1,β1,&gamma1 recombinant isoform of AMPK.	-	6.15	pEC50	700	nM	EC50	Cell Metab (2006) 3: 403-16 [PMID:16753576]
GtoPdb	Activation of AMPK purified from rat liver, which contains α1 and α2 catalytic subunits, with β1 and γ1 regulatory subunits.	-	6.94	pEC50	116	nM	EC50	J Biol Chem (2007) 282: 32549-60 [PMID:17855357]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]