ChEMBL ligand: CHEMBL359965 (Allicin, Diallyl Thiosulfinate)
cathepsin B/Cathepsin B in Human [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858] There should be some charts here, you may need to enable JavaScript!
cathepsin L/Cathepsin L in Human [ChEMBL: CHEMBL3837] [GtoPdb: 2351] [UniProtKB: P07711] There should be some charts here, you may need to enable JavaScript!
Mitochondrial oxodicarboxylate carrier/Mitochondrial 2-oxodicarboxylate carrier in Human [ChEMBL: CHEMBL4680040] [GtoPdb: 1057] [UniProtKB: Q9BQT8] There should be some charts here, you may need to enable JavaScript!
Plasmodium berghei [ChEMBL: CHEMBL612653] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium yoelii [ChEMBL: CHEMBL612889] There should be some charts here, you may need to enable JavaScript!
Rhodesain in Trypanosoma brucei rhodesiense [ChEMBL: CHEMBL4188] [UniProtKB: Q95PM0] There should be some charts here, you may need to enable JavaScript!
Telomerase reverse transcriptase in Human [ChEMBL: CHEMBL2916] [UniProtKB: O14746] There should be some charts here, you may need to enable JavaScript!
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] TRPA1/Transient receptor potential cation channel subfamily A member 1 in Mouse [ChEMBL: CHEMBL1075310] [GtoPdb: 485] [UniProtKB: Q8BLA8] There should be some charts here, you may need to enable JavaScript!
TRPV1/Vanilloid receptor in Rat [ChEMBL: CHEMBL5102] [GtoPdb: 507] [UniProtKB: O35433] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858]
ChEMBL	Inhibition of cathepsin B	B	5.07	pKi	8600	nM	Ki	Bioorg. Med. Chem. Lett. (2010) 20: 5541-5543 [PMID:20692829]
cathepsin L/Cathepsin L in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3837] [GtoPdb: 2351] [UniProtKB: P07711]
ChEMBL	Inhibition of cathepsin L	B	5.03	pKi	9300	nM	Ki	Bioorg. Med. Chem. Lett. (2010) 20: 5541-5543 [PMID:20692829]
Mitochondrial oxodicarboxylate carrier/Mitochondrial 2-oxodicarboxylate carrier in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4680040] [GtoPdb: 1057] [UniProtKB: Q9BQT8]
ChEMBL	Inhibition of ODC (unknown origin) expressed in Escherichia coli after 30 mins in presence of [1-14C] L-ornithine by liquid scintillation counter analysis	B	7.96	pIC50	11	nM	IC50	J Nat Prod (2020) 83: 2518-2527 [PMID:32786875]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL	Antimalarial activity against liver stages of Plasmodium berghei assessed as human HepG2 cells assessed as inhibition of hepatic parasite growth after invasion of hepatocytes incubated for 48 hrs followed by compound wash out measured after 2 days by RT-PCR analysis	F	4.4	pIC50	39400	nM	IC50	J. Med. Chem. (2012) 55: 995-1012 [PMID:22122518]
ChEMBL	Antimalarial activity against liver stages of Plasmodium berghei infected in human HepG2 cells assessed as growth inhibition of hepatic parasite before invasion of hepatocytes incubated for 48 hrs followed by compound wash out measured after 3 days by RT-PCR analysis	F	5.17	pIC50	6800	nM	IC50	J. Med. Chem. (2012) 55: 995-1012 [PMID:22122518]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiparasitic activity against Plasmodium falciparum	F	5.28	pIC50	5210	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 5541-5543 [PMID:20692829]
Plasmodium yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612889]
ChEMBL	Antimalarial activity against liver stages of Plasmodium yoelii 17XNL expressing GFP infected in human HepG2 cells transfected with CD81 assessed as growth inhibition of hepatic parasite after 40 hrs by flow cytometry	F	4.4	pIC50	40000	nM	IC50	J. Med. Chem. (2012) 55: 995-1012 [PMID:22122518]
Rhodesain in Trypanosoma brucei rhodesiense (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4188] [UniProtKB: Q95PM0]
ChEMBL	Inhibition of Trypanosoma brucei rhodesiense rhodesain	B	5.27	pKi	5310	nM	Ki	Bioorg. Med. Chem. Lett. (2010) 20: 5541-5543 [PMID:20692829]
Telomerase reverse transcriptase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2916] [UniProtKB: O14746]
ChEMBL	Inhibition of telomerase in human SGC7901 cells by TRAP-PCR-ELISA	B	6.3	pIC50	500	nM	IC50	MedChemComm (2011) 2: 229-245
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
GtoPdb	-	-	5.1	pEC50	7943	nM	EC50	Proc Natl Acad Sci USA (2005) 102: 12248-52 [PMID:16103371]
ChEMBL	Activation of human TRPA1 channel	B	5.72	pEC50	1910	nM	EC50	J. Med. Chem. (2010) 53: 5085-5107 [PMID:20356305]
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075310] [GtoPdb: 485] [UniProtKB: Q8BLA8]
ChEMBL	Activation of mouse TRPA1 channel	B	5.88	pEC50	1320	nM	EC50	J. Med. Chem. (2010) 53: 5085-5107 [PMID:20356305]
GtoPdb	-	-	5.9	pEC50	-	-	-	Curr Biol (2005) 15: 929-34 [PMID:15916949]
TRPV1/Vanilloid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5102] [GtoPdb: 507] [UniProtKB: O35433]
ChEMBL	Activation of rat TRPV1 channel	B	4.29	pEC50	51220	nM	EC50	J. Med. Chem. (2010) 53: 5085-5107 [PMID:20356305]
GtoPdb	-	-	4.6	pEC50	-	-	-	Curr Biol (2005) 15: 929-34 [PMID:15916949]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]