SB220025 [Ligand Id: 6038] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL274064 (SB-220025)
  • mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
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  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL Inhibition of recombinant ERK2 B 4.72 pIC50 19000 nM IC50 Bioorg Med Chem Lett (2008) 18: 5372-5376 [PMID:18835158]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL Inhibition against Mitogen-activated protein kinase p38 alpha B 7.7 pIC50 20 nM IC50 Bioorg Med Chem Lett (2001) 11: 2867-2870 [PMID:11597418]
ChEMBL Inhibitory concentration against mitogen-activated protein kinase p38 alpha B 7.7 pIC50 20 nM IC50 Bioorg Med Chem Lett (2001) 11: 1123-1126 [PMID:11354358]
GtoPdb - - 7.72 pIC50 19 nM IC50 Bioorg Med Chem Lett (2001) 11: 2867-70 [PMID:11597418]
ChEMBL Inhibition of p38 alpha kinase B 7.72 pIC50 19 nM IC50 Bioorg Med Chem Lett (2001) 11: 2867-2870 [PMID:11597418]
ChEMBL Inhibition of human MAPK p38alpha B 7.72 pIC50 19 nM IC50 Bioorg Med Chem (2010) 18: 2204-2218 [PMID:20188577]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]