SB220025 [Ligand Id: 6038] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL274064 (SB-220025) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
| ChEMBL | Inhibition of recombinant ERK2 | B | 4.72 | pIC50 | 19000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5372-5376 [PMID:18835158] |
| mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
| ChEMBL | Inhibition against Mitogen-activated protein kinase p38 alpha | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 2867-2870 [PMID:11597418] |
| ChEMBL | Inhibitory concentration against mitogen-activated protein kinase p38 alpha | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1123-1126 [PMID:11354358] |
| GtoPdb | - | - | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 2867-70 [PMID:11597418] |
| ChEMBL | Inhibition of p38 alpha kinase | B | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 2867-2870 [PMID:11597418] |
| ChEMBL | Inhibition of human MAPK p38alpha | B | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem (2010) 18: 2204-2218 [PMID:20188577] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
