Compound class:
Synthetic organic
Comment: SBI-0206965 inhibits the autophagy regulating kinase ULK1 in biochemical and cellular assays (measuring inhibition of phosphorylation of the downstream substrates VPS34 and Beclin1), and is a tool compound for experimental applications [1]. UKL1 and -2 are the only serine/threonine (S/T) kinases in the core autophagy pathway, and they are considered to be relevant druggable targets based on their participation at the first committed step towards autophagy. Because tumours can become addicted to autophagy for survival, inhibition of the autophagy pathway has been examined as a novel approach to cancer therapy that might be applicable across a broad range of cancer types.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
2-[5-bromo-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]oxy-N-methylbenzamide |
Database Links ![]() |
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CAS Registry No. | 1884220-36-3 (source: PubChem) |
ChEMBL Ligand | CHEMBL4128069 |
GtoPdb PubChem SID | 440816708 |
PubChem CID | 92044402 |
RCSB PDB Ligand | EDJ |
Search Google for chemical match using the InChIKey | NEXGBSJERNQRSV-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | NEXGBSJERNQRSV |
UniChem Compound Search for chemical match using the InChIKey | NEXGBSJERNQRSV-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | NEXGBSJERNQRSV-UHFFFAOYSA-N |