ChEMBL ligand: CHEMBL4128069
unc-51 like autophagy activating kinase 1/Serine/threonine-protein kinase ULK1 in Human [ChEMBL: CHEMBL6006] [GtoPdb: 2271] [UniProtKB: O75385] There should be some charts here, you may need to enable JavaScript!
unc-51 like autophagy activating kinase 2/Serine/threonine-protein kinase ULK2 in Human [ChEMBL: CHEMBL5435] [GtoPdb: 2272] [UniProtKB: Q8IYT8] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
unc-51 like autophagy activating kinase 1/Serine/threonine-protein kinase ULK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6006] [GtoPdb: 2271] [UniProtKB: O75385]
ChEMBL	Inhibition of ULK1 (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRET assay	B	6.11	pIC50	785	nM	IC50	J Med Chem (2020) 63: 14609-14625 [PMID:33200929]
ChEMBL	Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay	B	6.89	pIC50	130	nM	IC50	J Med Chem (2020) 63: 14609-14625 [PMID:33200929]
GtoPdb	-	-	6.89	pIC50	130	nM	IC50	Mol Cell (2015) 59: 285-97 [PMID:26118643]
ChEMBL	Inhibition of GST-tagged ULK1 (unknown origin)	B	6.97	pIC50	108	nM	IC50	J Med Chem (2018) 61: 6491-6500 [PMID:29509411]
ChEMBL	Inhibition of FLAG-tagged ULK1 (unknown origin) expressed in HEK293T cells using GST-labelled Atg101 as substrate in presence of gamma-[32]P-ATP	B	6.97	pIC50	108	nM	IC50	J Med Chem (2018) 61: 4656-4687 [PMID:29211480]
ChEMBL	Inhibition of ULK1 (unknown origin) by 32P-ATP radio active assay	B	6.97	pIC50	108	nM	IC50	Eur J Med Chem (2020) 208: 112782-112782 [PMID:32961380]
unc-51 like autophagy activating kinase 2/Serine/threonine-protein kinase ULK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5435] [GtoPdb: 2272] [UniProtKB: Q8IYT8]
ChEMBL	Inhibition of ULK2 (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRET assay	B	5.34	pIC50	4578	nM	IC50	J Med Chem (2020) 63: 14609-14625 [PMID:33200929]
ChEMBL	Inhibition of recombinant human ULK2 (1 to 478 residues) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay	B	5.61	pIC50	2448	nM	IC50	J Med Chem (2020) 63: 14609-14625 [PMID:33200929]
ChEMBL	Inhibition of GST-tagged ULK2 (unknown origin)	B	6.15	pIC50	711	nM	IC50	J Med Chem (2018) 61: 6491-6500 [PMID:29509411]
ChEMBL	Inhibition of ULK2 (unknown origin)	B	6.15	pIC50	711	nM	IC50	Eur J Med Chem (2020) 208: 112782-112782 [PMID:32961380]
ChEMBL	Inhibition of ULK2 (unknown origin)	B	7.96	pIC50	11	nM	IC50	J Med Chem (2018) 61: 4656-4687 [PMID:29211480]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]