compound 5z [PMID: 8410981] [Ligand Id: 8893] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL307794 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DNA topoisomerase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387] | ||||||||
| ChEMBL | Inhibition of topoisomerase I activity was determined in vitro by using the cleavable complex assay(calf thymus) | B | 7.11 | pIC50 | 78 | nM | IC50 | J Med Chem (1995) 38: 395-401 [PMID:7853331] |
| ChEMBL | Ability to inhibit calf thymus topoisomerase I when assayed in the cleavable complex formation | B | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 2129-2132 |
| ChEMBL | Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells | B | 7.57 | pIC50 | 27 | nM | IC50 | J Med Chem (1993) 36: 2689-2700 [PMID:8410981] |
| ChEMBL | Effective concentration against DNA topoisomerase I | B | 7.3 | pEC50 | 50 | nM | EC50 | Bioorg Med Chem Lett (2004) 14: 5377-5381 [PMID:15454230] |
| DNA topoisomerase I in Bovine [GtoPdb: 2636] | ||||||||
| GtoPdb | Inhibition of pBR322 DNA cleavage by calf thymus DNA topoisomerase I. | - | 7.57 | pIC50 | 27 | nM | IC50 | J Med Chem (1993) 36: 2689-700 [PMID:8410981] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
