compound 5z [PMID: 8410981] [Ligand Id: 8893] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL307794 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DNA topoisomerase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387] | ||||||||
| ChEMBL | Inhibition of topoisomerase I activity was determined in vitro by using the cleavable complex assay(calf thymus) | B | 7.11 | pIC50 | 78 | nM | IC50 | J Med Chem (1995) 38: 395-401 [PMID:7853331] |
| ChEMBL | Ability to inhibit calf thymus topoisomerase I when assayed in the cleavable complex formation | B | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 2129-2132 |
| ChEMBL | Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells | B | 7.57 | pIC50 | 27 | nM | IC50 | J Med Chem (1993) 36: 2689-2700 [PMID:8410981] |
| ChEMBL | Effective concentration against DNA topoisomerase I | B | 7.3 | pEC50 | 50 | nM | EC50 | Bioorg Med Chem Lett (2004) 14: 5377-5381 [PMID:15454230] |
| DNA topoisomerase I in Bovine [GtoPdb: 2636] | ||||||||
| GtoPdb | Inhibition of pBR322 DNA cleavage by calf thymus DNA topoisomerase I. | - | 7.57 | pIC50 | 27 | nM | IC50 | J Med Chem (1993) 36: 2689-700 [PMID:8410981] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
