SK1-I [Ligand Id: 6622] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2376441 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| sphingosine kinase 1/Sphingosine kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4394] [GtoPdb: 2204] [UniProtKB: Q9NYA1] | ||||||||
| ChEMBL | Inhibition of sphingosine kinase 1 (unknown origin) | B | 5 | pKi | 10000 | nM | Ki | J Med Chem (2013) 56: 9310-9327 [PMID:24164513] |
| ChEMBL | Inhibition of human recombinant SphK1 expressed in Sf9 cells assessed as radiolabeled products using 5 uM sphingosine and 10 uM gamma[32P]ATP by liquid scintillation counting | B | 5 | pKi | 10000 | nM | Ki | J Med Chem (2015) 58: 1879-1899 [PMID:25643074] |
| ChEMBL | Inhibition of V5-His-tagged human SphK1 using sphingosine as substrate in presence of [gamma-32P]ATP | B | 5 | pKi | 10000 | nM | Ki | Eur J Med Chem (2017) 139: 461-481 [PMID:28822281] |
| sphingosine kinase 2/Sphingosine kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3023] [GtoPdb: 2205] [UniProtKB: Q9NRA0] | ||||||||
| ChEMBL | Inhibition of human recombinant SphK2 expressed in Sf9 cells assessed as radiolabeled products using 10 uM sphingosine and 10 uM gamma[32P]ATP by liquid scintillation counting | B | 4 | pKi | >100000 | nM | Ki | J Med Chem (2015) 58: 1879-1899 [PMID:25643074] |
| ChEMBL | Competitive inhibition of V5-His-tagged human SphK2 expressed in HEK293 cells assessed as S1P production using sphingosine and [gamma-32P]ATP as substrate by thin layer chromatography | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2014) 57: 5509-5524 [PMID:24471412] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
