L735821 [Ligand Id: 2592] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL332826
  • CCK2 receptor/Cholecystokinin B receptor in Human [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239]
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  • Voltage-gated potassium channel subunit Kv7.1 in Guinea pig [ChEMBL: CHEMBL5135] [UniProtKB: O70344]
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  • Kv7.1 in Human [GtoPdb: 560] [UniProtKB: P51787]
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  • Kv7.2 in Human [GtoPdb: 561] [UniProtKB: O43526]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CCK2 receptor/Cholecystokinin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239]
ChEMBL Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex. B 6 pIC50 >1000 nM IC50 J Med Chem (1997) 40: 3865-3868 [PMID:9397166]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of Ikr current in isolated guinea pig myocytes during a 0.5 s voltage clamp step from -50 to -10 mV. F 5.82 pIC50 1500 nM IC50 J Med Chem (1997) 40: 3865-3868 [PMID:9397166]
Voltage-gated potassium channel subunit Kv7.1 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5135] [UniProtKB: O70344]
ChEMBL Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricular myocytes B 7.51 pIC50 31 nM IC50 J Med Chem (2001) 44: 3764-3767 [PMID:11689063]
Kv7.1 in Human [GtoPdb: 560] [UniProtKB: P51787]
GtoPdb - - 7.5 pIC50 - - - Mol Pharmacol (2003) 64: 70-7 [PMID:12815162];
J Med Chem (1997) 40: 3865-8 [PMID:9397166]
Kv7.2 in Human [GtoPdb: 561] [UniProtKB: O43526]
GtoPdb - - 5.8 pIC50 - - - FEBS Lett (1998) 438: 171-6 [PMID:9827540]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]