ChEMBL ligand: CHEMBL374975 (Acide fusidique, Acido fusidico, Anhydrous fusidic acid, CEM-102, Fucidin caviject, Fucithalmic, Fusidate, Fusidic acid, NSC-56192, Ramycin, SQ 16,603, SQ-16603, Taksta)
ABCG2/ATP-binding cassette sub-family G member 2 in Human [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0] There should be some charts here, you may need to enable JavaScript!
ABCB11/Bile salt export pump in Human [ChEMBL: CHEMBL6020] [GtoPdb: 778] [UniProtKB: O95342] ABCB11/Bile salt export pump in Rat [ChEMBL: CHEMBL2073674] [GtoPdb: 778] [UniProtKB: O70127] There should be some charts here, you may need to enable JavaScript!
ABCC2/Canalicular multispecific organic anion transporter 1 in Rat [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ABCG2/ATP-binding cassette sub-family G member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0]
ChEMBL	Inhibition of ABCG2 (unknown origin) expressed in dog MDCK-II-BCRP cells incubated for 120 mins by transwell migration assay	B	4.28	pIC50	52000	nM	IC50	Eur J Med Chem (2022) 237: 114346-114346 [PMID:35483322]
ABCB11/Bile salt export pump in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6020] [GtoPdb: 778] [UniProtKB: O95342]
ChEMBL	Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	B	4.94	pIC50	11500	nM	IC50	Drug Metab Dispos (2012) 40: 130-138 [PMID:21965623]
ABCB11/Bile salt export pump in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073674] [GtoPdb: 778] [UniProtKB: O70127]
ChEMBL	TP_TRANSPORTER: inhibition of Taurocholate uptake in canalicular membrane vesicles of rat liver	F	5.66	pKi	2200	nM	Ki	Biochem Pharmacol (2002) 64: 151-158 [PMID:12106615]
ChEMBL	Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	B	4.76	pIC50	17400	nM	IC50	Drug Metab Dispos (2012) 40: 130-138 [PMID:21965623]
ABCC2/Canalicular multispecific organic anion transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120]
ChEMBL	TP_TRANSPORTER: inhibition of LTC4 uptake in Mrp2-expressing HEK cells	F	4.89	pKi	13000	nM	Ki	Biochem Pharmacol (2002) 64: 151-158 [PMID:12106615]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake in canalicular membrane vesicles of rat liver	F	5.12	pKi	7600	nM	Ki	Biochem Pharmacol (2002) 64: 151-158 [PMID:12106615]
ChEMBL	TP_TRANSPORTER: inhibition of LTC4 uptake in canalicular membrane vesicles of rat liver	F	5.26	pKi	5500	nM	Ki	Biochem Pharmacol (2002) 64: 151-158 [PMID:12106615]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by LDH assay	F	4.23	pIC50	59000	nM	IC50	Bioorg Med Chem Lett (2017) 27: 658-661 [PMID:28012840]
ChEMBL	Antiplasmodial activity against chloroquine sensitive Plasmodium falciparum NF54 infected in human RBC after 48 hrs by [3H]hypoxanthine incorporation assay	F	4.23	pIC50	59000	nM	IC50	Medchemcomm (2015) 6: 2023-2028
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 infected in human erythrocytes assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting	F	4.23	pIC50	59000	nM	IC50	Medchemcomm (2017) 8: 1152-1157 [PMID:30108825]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D10 infected in human RBC after 48 to 96 hrs by SYBR Green I dye-based fluorescence assay	F	4.28	pIC50	52800	nM	IC50	Medchemcomm (2015) 6: 2023-2028
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D10 after 48 hrs	F	4.28	pIC50	52800	nM	IC50	Medchemcomm (2017) 8: 1152-1157 [PMID:30108825]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 infected in erythrocytes after 48 hrs by giemsa staining based assay	F	4.3	pIC50	50000	nM	IC50	Bioorg Med Chem Lett (2017) 27: 658-661 [PMID:28012840]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay	F	4.72	pIC50	19000	nM	IC50	Bioorg Med Chem Lett (2017) 27: 658-661 [PMID:28012840]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]