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fusidic acid   Click here for help

GtoPdb Ligand ID: 10815

Synonyms: CEM-102 | CEM102 | Fucidin® | fusidate | sodium fusidate | Taksta®
Approved drug PDB Ligand
fusidic acid is an approved drug (UK (1979))
Compound class: Synthetic organic
Comment: Fusidic acid is an orally bioavailable fusidane antibacterial with activity against Gram +ve pathogens [2,4].

fusidic acid is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 104.06
Molecular weight 516.35
XLogP 5.9
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CC(=O)O[C@H]1C[C@]2([C@H](/C/1=C(/C(=O)O)\CCC=C(C)C)C[C@H]([C@@H]1[C@]2(C)CC[C@@H]2[C@]1(C)CC[C@H]([C@H]2C)O)O)C
Isomeric SMILES CC(=O)O[C@H]1C[C@]2([C@H](/C/1=C(/C(=O)O)\CCC=C(C)C)C[C@H]([C@@H]1[C@]2(C)CC[C@@H]2[C@]1(C)CC[C@H]([C@H]2C)O)O)C
InChI InChI=1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1
InChI Key IECPWNUMDGFDKC-MZJAQBGESA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. UK MHRA (1979)
IUPAC Name Click here for help
(2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid
International Nonproprietary Names Click here for help
INN number INN
1431 fusidic acid
Synonyms Click here for help
CEM-102 | CEM102 | Fucidin® | fusidate | sodium fusidate | Taksta®
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Fusidic acid
Other databases
ChEMBL Ligand CHEMBL374975
DrugCentral Ligand 1261
GtoPdb PubChem SID 405560256
LIPID MAPS LMPR0106040001
PubChem CID 3000226
RCSB PDB Ligand FUA
Search Google for chemical match using the InChIKey IECPWNUMDGFDKC-MZJAQBGESA-N
Search Google for chemicals with the same backbone IECPWNUMDGFDKC
Search PubMed clinical trials fusidic acid
Search PubMed titles fusidic acid
Search PubMed titles/abstracts fusidic acid
UniChem Compound Search for chemical match using the InChIKey IECPWNUMDGFDKC-MZJAQBGESA-N
UniChem Connectivity Search for chemical match using the InChIKey IECPWNUMDGFDKC-MZJAQBGESA-N

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MedChemExpress
Fusidic acid (links to external site)
Cat. No. HY-B1350