VUF5574 [Ligand Id: 3280] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL70880 (VUF-5574) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
| GtoPdb | - | - | 5 | pKi | <10000 | nM | Ki | J Med Chem (1998) 41: 3987-93 [PMID:9767636] |
| ChEMBL | Displacement of [3H]DPCPX binding to adenosine A1 receptor of rat brain cortical membrane | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2001) 44: 749-762 [PMID:11262085] |
| A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] | ||||||||
| GtoPdb | - | - | 5 | pKi | <10000 | nM | Ki | J Med Chem (1998) 41: 3987-93 [PMID:9767636] |
| ChEMBL | Displacement of [3H]-CGS- 21680 binding in adenosine A2A receptor of rat striatal membrane | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2001) 44: 749-762 [PMID:11262085] |
| A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
| ChEMBL | Percent displacement of [3H]DPCPX binding in human adenosine A2B receptor expressed in COS-7 cells | B | 5 | pKi | 10000 | nM | Ki | J Med Chem (2001) 44: 749-762 [PMID:11262085] |
| A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| ChEMBL | Binding affinity by its ability to displace [125I]AB-MECA from human adenosine A3 receptor expressed in HEK 293 cells | B | 5.39 | pKi | 4030 | nM | Ki | J Med Chem (2000) 43: 2227-2238 [PMID:10841801] |
| GtoPdb | - | - | 8.39 | pKi | 4.03 | nM | Ki | J Med Chem (2000) 43: 2227-38 [PMID:10841801] |
| ChEMBL | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in HEK 293 cells | B | 8.4 | pKi | 4 | nM | Ki | J Med Chem (2001) 44: 749-762 [PMID:11262085] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 5.6 | pIC50 | 2511.89 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
