IK-862 [Ligand Id: 8680] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL148169 (IK-682) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536] | ||||||||
| GtoPdb | - | - | 9.25 | pKi | 0.56 | nM | Ki | Bioorg Med Chem (2008) 16: 8781-94 [PMID:18790648] |
| ChEMBL | Inhibition of TACE catalytic domain by FRET assay | B | 10.22 | pKi | 0.06 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 54-57 [PMID:19054672] |
| ChEMBL | Inhibition of Tumor necrosis factor alpha secretion in LPS-stimulated human whole blood assay | F | 6.46 | pIC50 | 350 | nM | IC50 | J Med Chem (2002) 45: 4954-4957 [PMID:12408705] |
| ChEMBL | Inhibition of pTACE | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 2769-2774 [PMID:17368021] |
| ChEMBL | Inhibition of TACE | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem (2009) 17: 444-459 [PMID:19095454] |
| ChEMBL | Inhibition of TACE | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem (2009) 17: 444-459 [PMID:19095454] |
| ChEMBL | Inhibition of TACE | B | 9.25 | pIC50 | 0.56 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 34-39 [PMID:17064892] |
| ChEMBL | Inhibition of Tumor necrosis factor alpha secretion in LPS-stimulated human whole blood assay | F | 9.46 | pIC50 | 0.35 | nM | IC50 | J Med Chem (2002) 45: 4954-4957 [PMID:12408705] |
| ADAM17 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3332] [UniProtKB: O77636] | ||||||||
| ChEMBL | Affinity for Tumor necrosis factor alpha converting enzyme (TACE) | B | 9.25 | pKi | 0.56 | nM | Ki | J Med Chem (2002) 45: 4954-4957 [PMID:12408705] |
| ChEMBL | Inhibition of pig TACE | B | 9.25 | pKi | 0.56 | nM | Ki | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| ChEMBL | Inhibitory activity against porcine Tumor necrosis factor alpha converting enzyme. | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (2002) 45: 4954-4957 [PMID:12408705] |
| ADAM33/Disintegrin and metalloproteinase domain-containing protein 33 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6121] [GtoPdb: 1673] [UniProtKB: Q9BZ11] | ||||||||
| GtoPdb | - | - | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2008) 16: 8781-94 [PMID:18790648] |
| ChEMBL | Inhibition of ADAM33 | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
| ChEMBL | Affinity towards Matrix metalloprotease-1 (MMP-1) | B | 4.52 | pKi | 30000 | nM | Ki | J Med Chem (2002) 45: 4954-4957 [PMID:12408705] |
| ChEMBL | Inhibition of MMP1 | B | 4.52 | pKi | 30000 | nM | Ki | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| ChEMBL | Inhibition of MMP1 | B | 4.52 | pIC50 | 30000 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 34-39 [PMID:17064892] |
| MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
| ChEMBL | Affinity for Matrix metalloprotease-13 (MMP-13) | B | 5.85 | pKi | 1417 | nM | Ki | J Med Chem (2002) 45: 4954-4957 [PMID:12408705] |
| ChEMBL | Binding affinity to MMP13 | B | 5.85 | pKi | 1417 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 2769-2774 [PMID:17368021] |
| ChEMBL | Inhibition of MMP13 | B | 5.85 | pKi | 1417 | nM | Ki | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| ChEMBL | Inhibition of MMP13 | B | 5.85 | pIC50 | 1417 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 34-39 [PMID:17064892] |
| MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] | ||||||||
| ChEMBL | Affinity for Matrix metalloprotease-14 (MMP-14) | B | 4.8 | pKi | 15872 | nM | Ki | J Med Chem (2002) 45: 4954-4957 [PMID:12408705] |
| ChEMBL | Inhibition of MMP14 | B | 4.8 | pKi | 15872 | nM | Ki | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| MMP15/Matrix metalloproteinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2963] [GtoPdb: 1639] [UniProtKB: P51511] | ||||||||
| ChEMBL | Affinity for Matrix metalloprotease-15 (MMP-15) | B | 5.4 | pKi | 3997 | nM | Ki | J Med Chem (2002) 45: 4954-4957 [PMID:12408705] |
| ChEMBL | Inhibition of MMP15 | B | 5.4 | pKi | 3997 | nM | Ki | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| MMP16/Matrix metalloproteinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2200] [GtoPdb: 1640] [UniProtKB: P51512] | ||||||||
| ChEMBL | Affinity for Matrix metalloprotease-16 (MMP-16) | B | 5.8 | pKi | 1599 | nM | Ki | J Med Chem (2002) 45: 4954-4957 [PMID:12408705] |
| ChEMBL | Inhibition of MMP16 | B | 5.8 | pKi | 1599 | nM | Ki | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| ChEMBL | Affinity for Matrix metalloprotease-2 (MMP-2) | B | 5.69 | pKi | 2050 | nM | Ki | J Med Chem (2002) 45: 4954-4957 [PMID:12408705] |
| ChEMBL | Binding affinity to MMP2 | B | 5.69 | pKi | 2050 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 2769-2774 [PMID:17368021] |
| ChEMBL | Inhibition of MMP2 | B | 5.69 | pKi | 2050 | nM | Ki | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| ChEMBL | Inhibition of MMP2 | B | 5.69 | pIC50 | 2050 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 34-39 [PMID:17064892] |
| MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
| ChEMBL | Affinity for Matrix metalloprotease-3 (MMP-3) | B | 6.85 | pKi | 141 | nM | Ki | J Med Chem (2002) 45: 4954-4957 [PMID:12408705] |
| ChEMBL | Binding affinity to MMP3 | B | 6.85 | pKi | 141 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 2769-2774 [PMID:17368021] |
| ChEMBL | Inhibition of MMP3 | B | 6.85 | pKi | 141 | nM | Ki | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| ChEMBL | Inhibition of MMP3 | B | 6.85 | pIC50 | 141 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 34-39 [PMID:17064892] |
| MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237] | ||||||||
| ChEMBL | Affinity for Matrix metalloprotease-7 (MMP-7) | B | 6.59 | pKi | 259 | nM | Ki | J Med Chem (2002) 45: 4954-4957 [PMID:12408705] |
| ChEMBL | Binding affinity to MMP7 | B | 6.59 | pKi | 259 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 2769-2774 [PMID:17368021] |
| ChEMBL | Inhibition of MMP7 | B | 6.59 | pKi | 259 | nM | Ki | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] | ||||||||
| ChEMBL | Affinity for Matrix metalloprotease-8 (MMP-8) | B | 6.59 | pKi | 257 | nM | Ki | J Med Chem (2002) 45: 4954-4957 [PMID:12408705] |
| ChEMBL | Inhibition of MMP8 | B | 6.59 | pKi | 257 | nM | Ki | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
| ChEMBL | Affinity towards Matrix metalloprotease-9 (MMP-9) | B | 4.99 | pKi | 10340 | nM | Ki | J Med Chem (2002) 45: 4954-4957 [PMID:12408705] |
| ChEMBL | Inhibition of MMP9 | B | 4.99 | pKi | 10340 | nM | Ki | Bioorg Med Chem (2008) 16: 8781-8794 [PMID:18790648] |
| ChEMBL | Inhibition of MMP9 | B | 4.99 | pIC50 | 10340 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 34-39 [PMID:17064892] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
