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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1673

Nomenclature: ADAM33

Family: M12: Astacin/Adamalysin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 813 20p13 ADAM33 ADAM metallopeptidase domain 33
Mouse 1 797 2 63.26 cM Adam33 a disintegrin and metallopeptidase domain 33
Rat - - 3q36 Adam33 ADAM metallopeptidase domain 33
Database Links Click here for help
Specialist databases
MEROPS M12.244 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
IK-862 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.8 pKi 1
pKi 7.8 (Ki 1.5x10-8 M) [1]
INCB3619 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.0 pIC50 1
pIC50 6.0 (IC50 1.026x10-6 M) [1]
Immunopharmacology Comments
ADAM33 is implicated in the pathology of asthma [2].
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Disease Associations
Disease Name:  Asthma
Disease Synonyms:  no synonynms
Comment:  ADAM33 is implicated in the pathology of asthma.
Disease X-refs:  Disease Ontology: DOID:2841
OMIM: 600807
References:  2
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Asthma, susceptibility to
Disease Ontology: DOID:2841
OMIM: 600807


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1. Georgiadis D, Yiotakis A. (2008) Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem, 16 (19): 8781-94. [PMID:18790648]

2. Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, Torrey D, Pandit S, McKenny J, Braunschweiger K et al.. (2002) Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature, 418 (6896): 426-30. [PMID:12110844]

How to cite this page

M12: Astacin/Adamalysin: ADAM33. Last modified on 16/03/2017. Accessed on 24/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,