Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	607	8q21.3	MMP16	matrix metallopeptidase 16
Mouse	1	607	4 7.08 cM	Mmp16	matrix metallopeptidase 16
Rat	1	607	5q13	Mmp16	matrix metallopeptidase 16

Previous and Unofficial Names

MMP- X2 | membrane-type matrix metalloproteinase 3 | MT3MMP | MTMMP3 | Membrane type 3-MMP | matrix metallopeptidase 16 (membrane-inserted)

Database Links
Specialist databases
MEROPS	M10.016 (Hs)
Other databases
Alphafold	P51512 (Hs), Q9WTR0 (Mm), O35548 (Rn)
BRENDA	3.4.24.-
CATH/Gene3D	2.110.10.10, 3.40.390.10
ChEMBL Target	CHEMBL2200 (Hs)
DrugBank Target	P51512 (Hs)
Ensembl Gene	ENSG00000156103 (Hs), ENSMUSG00000028226 (Mm), ENSRNOG00000005708 (Rn)
Entrez Gene	4325 (Hs), 17389 (Mm), 65205 (Rn)
Human Protein Atlas	ENSG00000156103 (Hs)
KEGG Enzyme	3.4.24.-
KEGG Gene	hsa:4325 (Hs), mmu:17389 (Mm), rno:65205 (Rn)
OMIM	602262 (Hs)
Pharos	P51512 (Hs)
RefSeq Nucleotide	NM_005941 (Hs), NM_019724 (Mm), NM_080776 (Rn)
RefSeq Protein	NP_005932 (Hs), NP_062698 (Mm), NP_542954 (Rn)
UniProtKB	P51512 (Hs), Q9WTR0 (Mm), O35548 (Rn)
Wikipedia	MMP16 (Hs)

Enzyme Reaction
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference SL422 Hs Inhibition 7.5 pKi 2 ⤷ pKi 7.5 (Ki 3.5x10-8 M) [2] ilomastat Hs Inhibition 8.1 pIC50 1 ⤷ pIC50 8.1 (IC50 8x10-9 M) [1]
Inhibitor Comments
SL422 is a broad-spectrum inhibitor of MMP enzymes [2].