indusatumab vedotin   Click here for help

GtoPdb Ligand ID: 8718

Synonyms: 5F9vcMMAE [6] | MLN-0264 | MLN0264 | TAK-264 | TAK264
Compound class: Antibody
Comment: Indusatumab vedotin was a clinical lead antibody-drug conjugate (ADC). It comprises an anti-guanylate cyclase 2C (GUCY2C) antibody linked to the synthetic antineoplastic toxin monomethyl auristatin E (MMAE, aka vedotin; PubChem CID 11542188).
Peptide sequence information for this antibody is available from its IMGT/mAb-DB record.
A BLAST search of patented peptide sequences reveals that the heavy and light chain variable regions of indusatumab are identical to SEQ ID NO: 18 and SEQ ID NO: 20 respectively, from patent US8785600 B2 [6]. The patent also describes the toxin conjugation methodology.
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Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
10033 indusatumab vedotin
Synonyms Click here for help
5F9vcMMAE [6] | MLN-0264 | MLN0264 | TAK-264 | TAK264
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 532
Other databases
GtoPdb PubChem SID 252827376
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