indusatumab vedotin

Ligand id: 8718

Name: indusatumab vedotin

Compound class Antibody
International Nonproprietary Names
INN number INN
10033 indusatumab vedotin
5F9vcMMAE [4] | MLN-0264 | MLN0264
Indusatumab vedotin is an investigational antibody-drug conjugate (ADC), with an anti-guanylate cyclase 2C (GUCY2C) antibody linked to the synthetic antineoplastic toxin monomethyl auristatin E (MMAE, aka vedotin; PubChem CID 11542188).
Peptide sequence information for this antibody is available from its IMGT/mAb-DB record.
A BLAST search of patented peptide sequences reveals that the heavy and light chain variable regions of indusatumab are identical to SEQ ID NO: 18 and SEQ ID NO: 20 respectively, from patent US8785600 B2 [4]. The patent also describes the toxin conjugation methodology.
Database Links
Specialist databases
IMGT/mAb-DB 532
Other databases
GtoPdb PubChem SID 252827376
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