compound 28 [PMID: 16460935] [Ligand Id: 8619] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL205904
  • coagulation factor X/Coagulation factor X in Human [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742]
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  • coagulation factor II, thrombin/Thrombin in Human [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
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  • plasminogen activator, tissue type/Tissue-type plasminogen activator in Human [ChEMBL: CHEMBL1873] [GtoPdb: 2392] [UniProtKB: P00750]
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  • plasminogen activator, urokinase/Urokinase-type plasminogen activator in Human [ChEMBL: CHEMBL3286] [GtoPdb: 2393] [UniProtKB: P00749]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742]
ChEMBL Inhibition of F10a B 4.94 pKi 11400 nM Ki Bioorg Med Chem Lett (2006) 16: 2200-2204 [PMID:16460935]
complement C1s/Complement C1s in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3913] [GtoPdb: 2335] [UniProtKB: P09871]
GtoPdb - - 8 pKi 10 nM Ki Bioorg Med Chem Lett (2006) 16: 2200-4 [PMID:16460935]
ChEMBL Inhibition of C1S B 8 pKi 10 nM Ki Bioorg Med Chem Lett (2006) 16: 2200-2204 [PMID:16460935]
plasminogen/Plasminogen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747]
ChEMBL Inhibition of plasmin B 4.89 pKi >13000 nM Ki Bioorg Med Chem Lett (2006) 16: 2200-2204 [PMID:16460935]
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
ChEMBL Inhibition of thrombin B 4.82 pKi >15000 nM Ki Bioorg Med Chem Lett (2006) 16: 2200-2204 [PMID:16460935]
plasminogen activator, tissue type/Tissue-type plasminogen activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1873] [GtoPdb: 2392] [UniProtKB: P00750]
ChEMBL Inhibition of tPA B 5 pKi >10000 nM Ki Bioorg Med Chem Lett (2006) 16: 2200-2204 [PMID:16460935]
plasminogen activator, urokinase/Urokinase-type plasminogen activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3286] [GtoPdb: 2393] [UniProtKB: P00749]
ChEMBL Inhibition of uPA B 5 pKi >10000 nM Ki Bioorg Med Chem Lett (2006) 16: 2200-2204 [PMID:16460935]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]