peficitinib [Ligand Id: 8315] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3137308 (ASP015K, Peficitinib, ASP-015K, JNJ-54781532)
  • Janus kinase 1/Tyrosine-protein kinase JAK1 in Human [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458]
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  • Janus kinase 2/Tyrosine-protein kinase JAK2 in Human [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
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  • Janus kinase 3/Tyrosine-protein kinase JAK3 in Human [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
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  • tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Janus kinase 1/Tyrosine-protein kinase JAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458]
GtoPdb - - 8.4 pIC50 4 nM IC50 J. Pharmacol. Sci. (2017) 133: 25-33 [PMID:28117214]
ChEMBL Inhibition of JAK1 (unknown origin) B 8.41 pIC50 3.9 nM IC50 J. Med. Chem. (2015) 58: 7596-7602 [PMID:26351728]
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
GtoPdb - - 8.3 pIC50 5 nM IC50 J. Pharmacol. Sci. (2017) 133: 25-33 [PMID:28117214]
ChEMBL Inhibition of JAK2 (unknown origin) B 8.3 pIC50 5 nM IC50 J. Med. Chem. (2015) 58: 7596-7602 [PMID:26351728]
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
ChEMBL Inhibition of JAK3 (unknown origin) B 9.15 pIC50 0.71 nM IC50 J. Med. Chem. (2015) 58: 7596-7602 [PMID:26351728]
tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597]
GtoPdb - - 8.3 pIC50 5 nM IC50 J. Pharmacol. Sci. (2017) 133: 25-33 [PMID:28117214]
ChEMBL Inhibition of Tyk2 (unknown origin) B 8.32 pIC50 4.8 nM IC50 J. Med. Chem. (2015) 58: 7596-7602 [PMID:26351728]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]