abelacimab   Click here for help

GtoPdb Ligand ID: 12417

Synonyms: MAA-868 | MAA868 | NVS250519
Compound class: Antibody
Comment: Abelacimab (MAA868) is a humanized monoclonal antibody that binds to the catalytic domain of both coagulation factor XI (FXI, F11) and activated FXI (FXIa) [3], and which was designed for antithrombotic potential. It locks FXIa into a conformation that cannot be activated by FXIIa or thrombin [1-2]. Inhbiting FXI/FXIa produces anticoagulant effects without adversly affecting normal hemostasis. Anti-FXI mAbs offer an alternative FXI-targeting strategy to investigational small molecule FXI inhibitors like asundexian and milvexian. Osocimab is another clinical stage anti-FXI mAb.
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Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
10881 abelacimab
Synonyms Click here for help
MAA-868 | MAA868 | NVS250519
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 844
Other databases
GtoPdb PubChem SID 479821208
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