MQ1 [Ligand Id: 8587] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2059420 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| MCH1 receptor/Melanin-concentrating hormone receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL344] [GtoPdb: 280] [UniProtKB: Q99705] | ||||||||
| ChEMBL | Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH-stimulated arachidonic acid release after 45 mins by liquid scintillation counting | F | 8.54 | pIC50 | 2.9 | nM | IC50 | J Med Chem (2012) 55: 4336-4351 [PMID:22490048] |
| ChEMBL | Displacement of [125I]MCH from human MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting | B | 8.96 | pIC50 | 1.1 | nM | IC50 | J Med Chem (2012) 55: 4336-4351 [PMID:22490048] |
| GtoPdb | - | - | 8.96 | pIC50 | 1.1 | nM | IC50 |
J Med Chem (2012) 55: 4336-51 [PMID:22490048]; Br J Pharmacol (2014) 171: 1287-98 [PMID:24670150] |
| MCH1 receptor/Melanin-concentrating hormone receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075228] [GtoPdb: 280] [UniProtKB: P97639] | ||||||||
| ChEMBL | Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting | B | 8.72 | pIC50 | 1.9 | nM | IC50 | J Med Chem (2012) 55: 4336-4351 [PMID:22490048] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
