LY-288513 [Ligand Id: 902] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL117281 (LY-288512, LY-288513) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551] | ||||||||
| ChEMBL | Half maximal inhibition of specific binding of [125I]-Bolton-Hunter CCK-8 to Cholecystokinin type A receptor in the rat pancreas | B | 5.19 | pIC50 | 6400 | nM | IC50 | J Med Chem (2000) 43: 3505-3517 [PMID:11000005] |
| ChEMBL | The compound was tested for its activity to inhibit the binding of [3H]-L-364,718 to Cholecystokinin type A receptor in rat pancreas | B | 5.19 | pIC50 | 6400 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 875-880 |
| Cholecystokinin A receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3501] [UniProtKB: Q63931] | ||||||||
| ChEMBL | Displacement of [125I]BH-CCK-8S from CC1 receptor expressed in guinea pig pancreatic cells | B | 4.7 | pKi | 19952.62 | nM | Ki | J Med Chem (2008) 51: 565-573 [PMID:18201065] |
| CCK2 receptor in Human [GtoPdb: 77] [UniProtKB: P32239] | ||||||||
| GtoPdb | - | - | 7 | pIC50 | - | - | - | Neuropeptides (1996) 30: 359-63 [PMID:8914862] |
| CCK2 receptor/Cholecystokinin B receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2854] [GtoPdb: 77] [UniProtKB: P56481] | ||||||||
| ChEMBL | Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex | B | 6.43 | pIC50 | 370 | nM | IC50 | J Med Chem (2000) 43: 3505-3517 [PMID:11000005] |
| ChEMBL | The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5 | B | 6.43 | pIC50 | 370 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 875-880 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
