cytisine [Ligand Id: 5347] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL497939 (6039 Sopharma, Baptitoxine, Cytisine, Cytisinicline, Cytiton, NSC-407282, Sophorine, Tabex, Ulexine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Acetylcholine receptor in Torpedo californica (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096975] [UniProtKB: P02710, P02712, P02714, P02718] | ||||||||
| ChEMBL | Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha1 beta gamma delta of electroplax | B | 6.6 | pKi | 250 | nM | Ki | J. Med. Chem. (2005) 48: 3474-3477 [PMID:15887955] |
| nicotinic acetylcholine receptor α1 subunit/nicotinic acetylcholine receptor γ subunit/nicotinic acetylcholine receptor β1 subunit/nicotinic acetylcholine receptor δ subunit/Acetylcholine receptor; alpha1/beta1/delta/gamma in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907588] [GtoPdb: 462, 475, 471, 476] [UniProtKB: P02708, P07510, P11230, Q07001] | ||||||||
| ChEMBL | Binding affinity to human Nicotinic acetylcholine receptor alpha-1-beta-gamma-delta expressed in HEK 293 cells using [3H]alpha-bungarotoxin | B | 6.6 | pKi | 250 | nM | Ki | Bioorg. Med. Chem. Lett. (2005) 15: 4889-4897 [PMID:16171993] |
| ChEMBL | Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptors | F | 7.96 | pEC50 | 11 | nM | EC50 | Bioorg. Med. Chem. Lett. (2005) 15: 1221-1224 [PMID:15686946] |
| Acetylcholine receptor protein alpha chain in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3097] [UniProtKB: P02710] | ||||||||
| ChEMBL | Displacement of [3H]alpha-BGT from nAChR in Torpedo nobiliana electric organs membranes by scintillation counting method | B | 5.45 | pIC50 | 3530 | nM | IC50 | J Pesticide Sci (1995) 20: 49-56 |
| Acetylcholine receptor protein delta chain in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3916] [UniProtKB: P02718] | ||||||||
| ChEMBL | Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor subtype TE671 (muscle) | B | 4 | pEC50 | 100000 | nM | EC50 | J. Med. Chem. (1997) 40: 4169-4194 [PMID:9435889] |
| nicotinic acetylcholine receptor α3 subunit/nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor α2 subunit/nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor β3 subunit/nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α5 subunit/nicotinic acetylcholine receptor α6 subunit/nicotinic acetylcholine receptor α9 subunit/nicotinic acetylcholine receptor α7 subunit/nicotinic acetylcholine receptor α10 subunit/Neuronal acetylcholine receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094110] [GtoPdb: 464, 465, 463, 472, 473, 474, 466, 467, 469, 468, 470] [UniProtKB: P04757, P09483, P12389, P12390, P12391, P12392, P20420, P43143, P43144, Q05941, Q9JLB5] | ||||||||
| ChEMBL | Binding affinity towards rat forebrain nicotinic acetylcholine receptor using [3H]EB as radioligand | B | 8.6 | pKi | 2.5 | nM | Ki | Bioorg. Med. Chem. Lett. (2004) 14: 1845-1848 [PMID:15050613] |
| ChEMBL | Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor subtype PC12 (ganglionic) | B | 5 | pEC50 | 10000 | nM | EC50 | J. Med. Chem. (1997) 40: 4169-4194 [PMID:9435889] |
| nicotinic acetylcholine receptor α2 subunit/nicotinic acetylcholine receptor β2 subunit/Neuronal acetylcholine receptor; alpha2/beta2 in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907592] [GtoPdb: 463, 472] [UniProtKB: P12389, P12390] | ||||||||
| ChEMBL | Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligand | B | 8.85 | pKi | 1.4 | nM | Ki | Bioorg. Med. Chem. Lett. (2004) 14: 1845-1848 [PMID:15050613] |
| ChEMBL | Displacement of [3H]epibatidine from rat alpha-2-beta-2 nACHR expressed in human HEK293 cells | B | 8.97 | pKi | 1.07 | nM | Ki | J. Med. Chem. (2006) 49: 2673-2676 [PMID:16640326] |
| nicotinic acetylcholine receptor α2 subunit/nicotinic acetylcholine receptor β4 subunit/Neuronal acetylcholine receptor; alpha2/beta4 in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907590] [GtoPdb: 463, 474] [UniProtKB: P12389, P12392] | ||||||||
| ChEMBL | Displacement of [3H]epibatidine from rat alpha-2-beta-4 nACHR expressed in human HEK293 cells | B | 8.27 | pKi | 5.41 | nM | Ki | J. Med. Chem. (2006) 49: 2673-2676 [PMID:16640326] |
| nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α3 subunit/Neuronal acetylcholine receptor; alpha3/beta2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2109234] [GtoPdb: 472, 464] [UniProtKB: P17787, P32297] | ||||||||
| ChEMBL | Effective concentration against Nicotinic acetylcholine receptor alpha3-beta2 expressed in xenopus oocytes | B | 4.17 | pEC50 | 67000 | nM | EC50 | J. Med. Chem. (2005) 48: 4705-4745 [PMID:16033252] |
| nicotinic acetylcholine receptor α3 subunit/nicotinic acetylcholine receptor β2 subunit/Neuronal acetylcholine receptor; alpha3/beta2 in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907587] [GtoPdb: 464, 472] [UniProtKB: P04757, P12390] | ||||||||
| ChEMBL | Displacement of [3H]epibatidine from rat alpha-3-beta-2 nACHR expressed in human HEK293 cells | B | 7.43 | pKi | 37.2 | nM | Ki | J. Med. Chem. (2006) 49: 2673-2676 [PMID:16640326] |
| ChEMBL | Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in HEK293 cells using [3H]EB as radioligand | B | 7.43 | pKi | 37 | nM | Ki | Bioorg. Med. Chem. Lett. (2004) 14: 1845-1848 [PMID:15050613] |
| nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α3 subunit/Neuronal acetylcholine receptor; alpha3/beta4 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907594] [GtoPdb: 474, 464] [UniProtKB: P30926, P32297] | ||||||||
| ChEMBL | Displacement of [3H]epibatidine from human alpha3beta4 nAChR in IMR32 cells | B | 5.81 | pKi | 1560 | nM | Ki | Bioorg. Med. Chem. Lett. (2008) 18: 2316-2319 [PMID:18356044] |
| ChEMBL | Inhibition of [3H]epibatidine binding to nicotinic acetylcholine receptor alpha3-beta4 of human IMR32 cells | B | 6.08 | pKi | 840 | nM | Ki | J. Med. Chem. (2005) 48: 3474-3477 [PMID:15887955] |
| ChEMBL | Binding affinity to human Nicotinic acetylcholine receptor alpha3-beta4 expressed in IMR32 cells using [3H]epibatidine | B | 6.08 | pKi | 840 | nM | Ki | Bioorg. Med. Chem. Lett. (2005) 15: 4889-4897 [PMID:16171993] |
| ChEMBL | Inhibition of [3H]epibatidine binding to nicotinic acetylcholine receptor alpha3-beta4 of IMR32 cells | B | 6.08 | pKi | 840 | nM | Ki | Bioorg. Med. Chem. Lett. (2005) 15: 2974-2979 [PMID:15908213] |
| ChEMBL | Displacement of [3H]epibatidine from human recombinant alpha-3-beta-4 nAChR in HEK293 cells by SPA assay | B | 6.28 | pKi | 525 | nM | Ki | Bioorg. Med. Chem. Lett. (2006) 16: 5493-5497 [PMID:16934977] |
| ChEMBL | Partial agonist activity at alpha3beta4 nAChR (unknown origin) | B | 6.32 | pKi | 480 | nM | Ki | J. Med. Chem. (2014) 57: 8204-8223 [PMID:24901260] |
| ChEMBL | Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK cells | B | 6.55 | pKi | 280 | nM | Ki | J. Nat. Prod. (2013) 76: 727-731 [PMID:23461628] |
| ChEMBL | Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor subtype IMR-32 (ganglionic) | B | 4.59 | pEC50 | 26000 | nM | EC50 | J. Med. Chem. (1997) 40: 4169-4194 [PMID:9435889] |
| nicotinic acetylcholine receptor α3 subunit/nicotinic acetylcholine receptor β4 subunit/Neuronal acetylcholine receptor; alpha3/beta4 in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907593] [GtoPdb: 464, 474] [UniProtKB: P04757, P12392] | ||||||||
| ChEMBL | Displacement of [3H]epibatidine from rat alpha3beta4 nACHR expressed in human HEK293 cells | B | 6.66 | pKi | 217 | nM | Ki | J. Med. Chem. (2006) 49: 2673-2676 [PMID:16640326] |
| ChEMBL | Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in HEK293 cells using [3H]EB as radioligand | B | 6.68 | pKi | 210 | nM | Ki | Bioorg. Med. Chem. Lett. (2004) 14: 1845-1848 [PMID:15050613] |
| ChEMBL | Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrs | B | 6.69 | pKi | 203 | nM | Ki | J. Med. Chem. (2010) 53: 8187-8191 [PMID:20979364] |
| ChEMBL | Effective concentration in KXalpha-3-beta-4R2 cells expressing rat nicotinic acetylcholine receptor alpha3-beta4 subunits | F | 7.6 | pEC50 | 25 | nM | EC50 | Bioorg. Med. Chem. Lett. (2005) 15: 1221-1224 [PMID:15686946] |
| nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907589] [GtoPdb: 472, 465] [UniProtKB: P17787, P43681] | ||||||||
| ChEMBL | Displacement of [3H]epibatidine from human recombinant alpha4beta2 nAChR in HEK293 cells by SPA assay | B | 8.59 | pKi | 2.59 | nM | Ki | Bioorg. Med. Chem. Lett. (2006) 16: 5493-5497 [PMID:16934977] |
| ChEMBL | Partial agonist activity at alpha4beta2 nAChR (unknown origin) | B | 8.7 | pKi | 2 | nM | Ki | J. Med. Chem. (2014) 57: 8204-8223 [PMID:24901260] |
| ChEMBL | Displacement of [3H]cytisine from human alpha4beta2 nAChR by Cheng-Prusoff equation analysis | B | 9.55 | pKi | 0.28 | nM | Ki | Bioorg Med Chem (2020) 28: 115820-115820 [PMID:33120080] |
| ChEMBL | Binding affinity against nicotinic acetylcholine receptor alpha4-beta2 in human HEK293 cells using [3H]- nicotine as radioligand | B | 9.64 | pKi | 0.23 | nM | Ki | Bioorg. Med. Chem. Lett. (2005) 15: 2974-2979 [PMID:15908213] |
| ChEMBL | Binding affinity for human Nicotinic acetylcholine receptor alpha4-beta2 expressed in HEK 293 cells using [3H]nicotine | B | 9.64 | pKi | 0.23 | nM | Ki | Bioorg. Med. Chem. Lett. (2005) 15: 4889-4897 [PMID:16171993] |
| ChEMBL | Inactivation of alpha4beta2* nAChR low affinity site (unknown origin) expressed in xenopus oocytes by electrophysiology method | B | 4.55 | pIC50 | 28000 | nM | IC50 | J. Med. Chem. (2014) 57: 8204-8223 [PMID:24901260] |
| ChEMBL | Inactivation of alpha4beta2* nAChR high affinity site (unknown origin) expressed in xenopus oocytes by electrophysiology method | B | 7.3 | pIC50 | 50 | nM | IC50 | J. Med. Chem. (2014) 57: 8204-8223 [PMID:24901260] |
| ChEMBL | Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha4-beta2 | B | 4.42 | pEC50 | 38000 | nM | EC50 | J. Med. Chem. (1997) 40: 4169-4194 [PMID:9435889] |
| ChEMBL | Activation of alpha4beta2* nAChR high affinity site (unknown origin) expressed in xenopus oocytes by electrophysiology method | B | 5.7 | pEC50 | 2000 | nM | EC50 | J. Med. Chem. (2014) 57: 8204-8223 [PMID:24901260] |
| ChEMBL | Change in membrane potential in K-177 cells expressing acetylcholine central neuronal receptor alpha4-beta2 subunits | F | 9.38 | pEC50 | 0.42 | nM | EC50 | Bioorg. Med. Chem. Lett. (2005) 15: 1221-1224 [PMID:15686946] |
| nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor β2 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907596] [GtoPdb: 465, 472] [UniProtKB: P09483, P12390] | ||||||||
| ChEMBL | in vitro binding affinity by inhibiting [3H]cytisine binding in rat brain tissue at Nicotinic acetylcholine receptor alpha4-beta2 | B | 8.38 | pKi | 4.2 | nM | Ki | J. Med. Chem. (2002) 45: 3041-3047 [PMID:12086489] |
| ChEMBL | In vitro binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 using [3H]cytisine in rat brain | B | 8.56 | pKi | 2.78 | nM | Ki | J. Med. Chem. (2001) 44: 4704-4715 [PMID:11741488] |
| ChEMBL | Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cortex | B | 8.68 | pKi | 2.1 | nM | Ki | J. Nat. Prod. (2013) 76: 727-731 [PMID:23461628] |
| ChEMBL | Displacement of [3H]epibatidine from rat forebrain alpha4beta2 nACHR | B | 8.72 | pKi | 1.92 | nM | Ki | J. Med. Chem. (2006) 49: 2673-2676 [PMID:16640326] |
| ChEMBL | Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrs | B | 8.82 | pKi | 1.53 | nM | Ki | J. Med. Chem. (2010) 53: 8187-8191 [PMID:20979364] |
| ChEMBL | Displacement of [3H]epibatidine from rat alpha-4-beta-2 nACHR expressed in human HEK293 cells | B | 8.82 | pKi | 1.51 | nM | Ki | J. Med. Chem. (2006) 49: 2673-2676 [PMID:16640326] |
| ChEMBL | Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in HEK293 cells using [3H]EB as radioligand | B | 8.82 | pKi | 1.5 | nM | Ki | Bioorg. Med. Chem. Lett. (2004) 14: 1845-1848 [PMID:15050613] |
| ChEMBL | Displacement of [3H]cytisine from rat alpha4beta2 nAChR in rat brain cell membrane | B | 8.97 | pKi | 1.06 | nM | Ki | Bioorg. Med. Chem. Lett. (2010) 20: 6667-6670 [PMID:20880707] |
| ChEMBL | Binding affinity to rat alpha4beta2 nAChR | B | 9 | pKi | 1 | nM | Ki | J. Med. Chem. (2012) 55: 9929-9945 [PMID:23025891] |
| ChEMBL | Displacement of (+/-)-[3H]epibatidine from alpha4beta2 nicotinic acetylcholine receptor in rat brain cortex membrane homogenates | B | 9.32 | pKi | 0.48 | nM | Ki | J. Med. Chem. (2009) 52: 4345-4357 [PMID:19548687] |
| ChEMBL | Displacement of [3H]nicotine from alpha4beta2 nAChR in Sprague-Dawley rat brain membrane | B | 9.37 | pKi | 0.43 | nM | Ki | Bioorg. Med. Chem. Lett. (2008) 18: 2316-2319 [PMID:18356044] |
| ChEMBL | Displacement of [3H]nicotine from rat alpha4beta2 nAChR by liquid scintillation counting | B | 9.4 | pKi | 0.4 | nM | Ki | Bioorg Med Chem (2020) 28: 115820-115820 [PMID:33120080] |
| ChEMBL | Displacement of (+/-)-[3H]epibatidine from alpha4beta2 nAChR in rat cortical membrane | B | 9.4 | pKi | 0.4 | nM | Ki | Bioorg. Med. Chem. (2010) 18: 4498-4508 [PMID:20478710] |
| ChEMBL | Displacement of [3H]cytisine from alpha4beta2 nicotinic acetylcholine receptor in rat brain cortex membrane homogenates | B | 9.47 | pKi | 0.34 | nM | Ki | J. Med. Chem. (2009) 52: 4345-4357 [PMID:19548687] |
| ChEMBL | Inhibition of [3H]-nicotine binding to nicotinic acetylcholine receptor alpha4-beta2 in rat cortex | B | 9.77 | pKi | 0.17 | nM | Ki | Bioorg. Med. Chem. Lett. (2005) 15: 2974-2979 [PMID:15908213] |
| ChEMBL | Inhibition of [3H]nicotine binding to nicotinic acetylcholine receptor alpha4-beta2 of rat cortex | B | 9.77 | pKi | 0.17 | nM | Ki | J. Med. Chem. (2005) 48: 3474-3477 [PMID:15887955] |
| ChEMBL | In vitro binding affinity towards (alpha-4)2(beta-2)3 neuronal nicotinic acetylcholine receptor in P2 membrane fractions of rat forebrain | B | 9.91 | pKi | 0.12 | nM | Ki | J. Med. Chem. (2003) 46: 2031-2048 [PMID:12747776] |
| ChEMBL | Displacement of [3H]epibatidine from Sprague-Dawley rat brain alpha4beta2 nAChR after 90 mins by liquid scintillation counting analysis | B | 9.91 | pKi | 0.12 | nM | Ki | Bioorg. Med. Chem. (2013) 21: 7309-7329 [PMID:24145137] |
| ChEMBL | Displacement of [3H]-epibatidine from rat forebrain alpha4beta2 nAChR | B | 9.91 | pKi | 0.12 | nM | Ki | Bioorg. Med. Chem. (2013) 21: 7283-7308 [PMID:24156938] |
| ChEMBL | Displacement of [3H]epibatidine from rat alpha4beta2 nAChR | B | 7.16 | pIC50 | 69.18 | nM | IC50 | Bioorg. Med. Chem. Lett. (2010) 20: 3683-3687 [PMID:20493692] |
| ChEMBL | In vitro binding affinity by inhibiting [3H]dopamine release in rat brain tissue at Nicotinic acetylcholine receptor alpha4-beta2 | F | 8.06 | pEC50 | 8.8 | nM | EC50 | J. Med. Chem. (2002) 45: 3041-3047 [PMID:12086489] |
| nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor β4 subunit/Neuronal acetylcholine receptor; alpha4/beta4 in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907595] [GtoPdb: 465, 474] [UniProtKB: P09483, P12392] | ||||||||
| ChEMBL | Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in HEK293 cells using [3H]EB as radioligand | B | 8.66 | pKi | 2.2 | nM | Ki | Bioorg. Med. Chem. Lett. (2004) 14: 1845-1848 [PMID:15050613] |
| ChEMBL | Displacement of [3H]epibatidine from rat alpha-4-beta-4 nACHR expressed in human HEK293 cells | B | 8.68 | pKi | 2.1 | nM | Ki | J. Med. Chem. (2006) 49: 2673-2676 [PMID:16640326] |
| nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2492] [GtoPdb: 468] [UniProtKB: P36544] | ||||||||
| ChEMBL | Partial agonist activity at alpha7 nAChR (unknown origin) | B | 5.23 | pKi | 5890 | nM | Ki | J. Med. Chem. (2014) 57: 8204-8223 [PMID:24901260] |
| ChEMBL | Inhibition of [3H]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha7 of IMR32 cells | B | 5.38 | pKi | 4200 | nM | Ki | Bioorg. Med. Chem. Lett. (2005) 15: 2974-2979 [PMID:15908213] |
| ChEMBL | Binding affinity to human Nicotinic acetylcholine receptor alpha7 expressed in IMR32 cells using [3H]alpha-bungarotoxin | B | 5.85 | pKi | 1420 | nM | Ki | Bioorg. Med. Chem. Lett. (2005) 15: 4889-4897 [PMID:16171993] |
| ChEMBL | Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha7 | B | 4.15 | pEC50 | 71000 | nM | EC50 | J. Med. Chem. (1997) 40: 4169-4194 [PMID:9435889] |
| ChEMBL | Effective concentration against Nicotinic acetylcholine receptor alpha 7 expressed in xenopus oocytes | B | 4.15 | pEC50 | 71000 | nM | EC50 | J. Med. Chem. (2005) 48: 4705-4745 [PMID:16033252] |
| nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4980] [GtoPdb: 468] [UniProtKB: Q05941] | ||||||||
| ChEMBL | Binding affinity to rat alpha7 nAChR | B | 5.1 | pKi | 8000 | nM | Ki | J. Med. Chem. (2012) 55: 9929-9945 [PMID:23025891] |
| ChEMBL | Displacement of [125I]alpha-bungarotoxin from rat alpha7 nAChR in GH4C1 cells | B | 5.24 | pKi | 5820 | nM | Ki | Bioorg. Med. Chem. Lett. (2008) 18: 2316-2319 [PMID:18356044] |
| ChEMBL | Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha-7 subunit in rat GH4C1 cells | B | 5.38 | pKi | 4200 | nM | Ki | J. Med. Chem. (2005) 48: 3474-3477 [PMID:15887955] |
| ChEMBL | Displacement of [3H]MLA from rat alpha7 nAChR by liquid scintillation counting | B | 5.77 | pKi | 1700 | nM | Ki | Bioorg Med Chem (2020) 28: 115820-115820 [PMID:33120080] |
| ChEMBL | Displacement of [125I]alpha-Bungarotoxin from alpha7 nAchR in rat brain cell membrane | B | 6 | pKi | 1000 | nM | Ki | Bioorg. Med. Chem. Lett. (2010) 20: 6667-6670 [PMID:20880707] |
| ChEMBL | Displacement of [125I]alpha-bungarotoxin from alpha7 nicotinic acetylcholine receptor in rat brain cortex membrane homogenates | B | 6.48 | pKi | 331 | nM | Ki | J. Med. Chem. (2009) 52: 4345-4357 [PMID:19548687] |
| ChEMBL | Displacement of [125I]alpha-Bungarotoxin from alpha7 nAChR in rat cortical membrane | B | 6.52 | pKi | 300 | nM | Ki | Bioorg. Med. Chem. (2010) 18: 4498-4508 [PMID:20478710] |
| ChEMBL | Displacement of [3H]methyllycaconitine from Sprague-Dawley rat brain alpha7 nAChR after 120 mins by liquid scintillation counting analysis | B | 6.58 | pKi | 261 | nM | Ki | Bioorg. Med. Chem. (2013) 21: 7309-7329 [PMID:24145137] |
| ChEMBL | Displacement of [3H]methyllycaconitine from rat forebrain alpha7 nAChR | B | 6.6 | pKi | 250 | nM | Ki | Bioorg. Med. Chem. (2013) 21: 7283-7308 [PMID:24156938] |
| ChEMBL | Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR from rat hippocampus | B | 6.64 | pKi | 230 | nM | Ki | J. Nat. Prod. (2013) 76: 727-731 [PMID:23461628] |
| ChEMBL | In vitro binding affinity towards Nicotinic acetylcholine receptor alpha7 using [125I]-alpha-Bungarotoxin in rat brain | B | 9.05 | pKi | 0.9 | nM | Ki | J. Med. Chem. (2001) 44: 4704-4715 [PMID:11741488] |
| Nicotinic acetylcholine receptor alpha 5 subunit in Musca domestica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366408] [UniProtKB: A9XFY4] | ||||||||
| ChEMBL | Displacement of [3H]alpha-bungarotoxin from nAChR in Musca domestica (house fly) head membrane after 60 min by scintillation counting | B | 5.91 | pKi | 1230 | nM | Ki | J Pesticide Sci (1992) 17: 231-236 |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]
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