ChEMBL ligand: CHEMBL2334891
D1 receptor/D(1A) dopamine receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] There should be some charts here, you may need to enable JavaScript!
D5 receptor/D(1B) dopamine receptor in Human [ChEMBL: CHEMBL1850] [GtoPdb: 218] [UniProtKB: P21918] There should be some charts here, you may need to enable JavaScript!
D2 receptor/D(2) dopamine receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] There should be some charts here, you may need to enable JavaScript!
D3 receptor/D(3) dopamine receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] There should be some charts here, you may need to enable JavaScript!
D4 receptor/D(4) dopamine receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
D1 receptor/D(1A) dopamine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL	Displacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hr	B	8.21	pKi	6.2	nM	Ki	Bioorg Med Chem Lett (2017) 27: 1437-1440 [PMID:28214075]
ChEMBL	Binding affinity to D1 receptor (unknown origin) assessed as inhibition constant	B	8.26	pKi	5.5	nM	Ki	J Med Chem (2024) 67: 12463-12484 [PMID:39038276]
ChEMBL	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	B	8.35	pKi	4.5	nM	Ki	Bioorg Med Chem (2013) 21: 856-868 [PMID:23332346]
D5 receptor/D(1B) dopamine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1850] [GtoPdb: 218] [UniProtKB: P21918]
ChEMBL	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cells after 1 hr	B	8.02	pKi	9.5	nM	Ki	Bioorg Med Chem Lett (2017) 27: 1437-1440 [PMID:28214075]
ChEMBL	Binding affinity to D5 receptor (unknown origin) assessed as inhibition constant	B	8.02	pKi	9.5	nM	Ki	J Med Chem (2024) 67: 12463-12484 [PMID:39038276]
D2 receptor/D(2) dopamine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	Displacement of [3H]spiperone from dopamine D2 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	B	7.04	pKi	91	nM	Ki	Bioorg Med Chem (2013) 21: 856-868 [PMID:23332346]
ChEMBL	Displacement of [3H]SCH23390 from human FLAG-tagged dopamine D2 receptor expressed in HEK293 cells after 1 hr	B	7.38	pKi	41.8	nM	Ki	Bioorg Med Chem Lett (2017) 27: 1437-1440 [PMID:28214075]
ChEMBL	Binding affinity to D2 receptor (unknown origin) assessed as inhibition constant	B	7.38	pKi	41.8	nM	Ki	J Med Chem (2024) 67: 12463-12484 [PMID:39038276]
D3 receptor/D(3) dopamine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL	Displacement of [3H]SCH23390 from human FLAG-tagged dopamine D3 receptor expressed in HEK293 cells after 1 hr	B	7.43	pKi	37.3	nM	Ki	Bioorg Med Chem Lett (2017) 27: 1437-1440 [PMID:28214075]
ChEMBL	Binding affinity to D3 receptor (unknown origin) assessed as inhibition constant	B	7.43	pKi	37.3	nM	Ki	J Med Chem (2024) 67: 12463-12484 [PMID:39038276]
D4 receptor/D(4) dopamine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL	Displacement of [3H]SCH23390 from human dopamine D4 receptor expressed in HEK293 cells after 1 hr	B	7.11	pKi	77.4	nM	Ki	Bioorg Med Chem Lett (2017) 27: 1437-1440 [PMID:28214075]
ChEMBL	Binding affinity to D4 receptor (unknown origin) assessed as inhibition constant	B	7.11	pKi	77.4	nM	Ki	J Med Chem (2024) 67: 12463-12484 [PMID:39038276]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]