isocorypalmine [Ligand Id: 13571] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2334891 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] | ||||||||
| ChEMBL | Displacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hr | B | 8.21 | pKi | 6.2 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 1437-1440 [PMID:28214075] |
| ChEMBL | Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter | B | 8.35 | pKi | 4.5 | nM | Ki | Bioorg Med Chem (2013) 21: 856-868 [PMID:23332346] |
| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Displacement of [3H]spiperone from dopamine D2 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter | B | 7.04 | pKi | 91 | nM | Ki | Bioorg Med Chem (2013) 21: 856-868 [PMID:23332346] |
| ChEMBL | Displacement of [3H]SCH23390 from human FLAG-tagged dopamine D2 receptor expressed in HEK293 cells after 1 hr | B | 7.38 | pKi | 41.8 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 1437-1440 [PMID:28214075] |
| D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
| ChEMBL | Displacement of [3H]SCH23390 from human FLAG-tagged dopamine D3 receptor expressed in HEK293 cells after 1 hr | B | 7.43 | pKi | 37.3 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 1437-1440 [PMID:28214075] |
| D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
| ChEMBL | Displacement of [3H]SCH23390 from human dopamine D4 receptor expressed in HEK293 cells after 1 hr | B | 7.11 | pKi | 77.4 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 1437-1440 [PMID:28214075] |
| D5 receptor/Dopamine D5 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1850] [GtoPdb: 218] [UniProtKB: P21918] | ||||||||
| ChEMBL | Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cells after 1 hr | B | 8.02 | pKi | 9.5 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 1437-1440 [PMID:28214075] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
