ChEMBL ligand: CHEMBL3115901
coagulation factor X/Coagulation factor X in Human [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742] There should be some charts here, you may need to enable JavaScript!
coagulation factor XI/Coagulation factor XI in Human [ChEMBL: CHEMBL2820] [GtoPdb: 2360] [UniProtKB: P03951] There should be some charts here, you may need to enable JavaScript!
coagulation factor II, thrombin/Thrombin in Human [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] There should be some charts here, you may need to enable JavaScript!
protein C, inactivator of coagulation factors Va and VIIIa/Vitamin K-dependent protein C in Human [ChEMBL: CHEMBL4444] [GtoPdb: 2396] [UniProtKB: P04070] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742]
ChEMBL	Competitive inhibition of human coagulation factor 10a using S-2765 as substrate	B	4.82	pKi	>15000	nM	Ki	Bioorg Med Chem Lett (2014) 24: 821-827 [PMID:24418773]
ChEMBL	Inhibition of human coagulation factor 10a using S-2765 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotometric analysis	B	4.36	pIC50	>44000	nM	IC50	Bioorg Med Chem Lett (2014) 24: 821-827 [PMID:24418773]
coagulation factor XI/Coagulation factor XI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2820] [GtoPdb: 2360] [UniProtKB: P03951]
ChEMBL	Competitive inhibition of human coagulation factor 11a using S-2366 as substrate	B	6.52	pKi	300	nM	Ki	Bioorg Med Chem Lett (2014) 24: 821-827 [PMID:24418773]
ChEMBL	Inhibition of human coagulation factor 11a using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotometric analysis	B	6.24	pIC50	580	nM	IC50	Bioorg Med Chem Lett (2014) 24: 821-827 [PMID:24418773]
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
ChEMBL	Competitive inhibition of human thrombin using S-2366 as substrate	B	6.3	pKi	500	nM	Ki	Bioorg Med Chem Lett (2014) 24: 821-827 [PMID:24418773]
ChEMBL	Inhibition of human thrombin using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotometric analysis	B	6.05	pIC50	900	nM	IC50	Bioorg Med Chem Lett (2014) 24: 821-827 [PMID:24418773]
protein C, inactivator of coagulation factors Va and VIIIa/Vitamin K-dependent protein C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4444] [GtoPdb: 2396] [UniProtKB: P04070]
ChEMBL	Competitive inhibition of human APC using S-2366 as substrate	B	7.4	pKi	40	nM	Ki	Bioorg Med Chem Lett (2014) 24: 821-827 [PMID:24418773]
GtoPdb	-	-	7.4	pKi	40	nM	Ki	Bioorg Med Chem Lett (2014) 24: 821-7 [PMID:24418773]
ChEMBL	Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotometric analysis	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem Lett (2014) 24: 821-827 [PMID:24418773]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]