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protein C, inactivator of coagulation factors Va and VIIIa

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Target not currently curated in GtoImmuPdb

Target id: 2396

Nomenclature: protein C, inactivator of coagulation factors Va and VIIIa

Family: S1: Chymotrypsin

This target is also described as a ligand entry: protein Cprotein Cprotein C

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 461 2q14.3 PROC protein C, inactivator of coagulation factors Va and VIIIa
Mouse - 460 18 B1 Proc protein C
Rat - 461 18p12 Proc protein C, inactivator of coagulation factors Va and VIIIa
Previous and Unofficial Names Click here for help
anticoagulant protein C | autoprothrombin IIA | PC | vitamin K-dependent protein C | blood coagulation factor XIV | protein C (inactivator of coagulation factors Va and VIIIa)
Database Links Click here for help
Specialist databases
MEROPS S01.218 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.21.69

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 37 [PMID: 24418773] Small molecule or natural product Primary target of this compound Hs Inhibition 7.4 pKi 1
pKi 7.4 (Ki 4x10-8 M) [1]
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0050728 negative regulation of inflammatory response IMP
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0050728 negative regulation of inflammatory response IMP
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Thrombophilia due to protein C deficiency, autosomal dominant
Synonyms: Hereditary thrombophilia due to congenital protein C deficiency [Orphanet: ORPHA745]
Thrombophilia [Disease Ontology: DOID:2452]
Disease Ontology: DOID:2452
OMIM: 176860
Orphanet: ORPHA745
Disease:  Thrombophilia due to protein C deficiency, autosomal recessive
Synonyms: Hereditary thrombophilia due to congenital protein C deficiency [Orphanet: ORPHA745]
Thrombophilia [Disease Ontology: DOID:2452]
Disease Ontology: DOID:2452
OMIM: 612304
Orphanet: ORPHA745

References

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1. Bach P, Knerr L, Fjellström O, Hansson K, Mattsson C, Gustafsson D. (2014) Design, synthesis, and SAR of a series of activated protein C (APC) inhibitors with selectivity against thrombin for the treatment of haemophilia. Bioorg Med Chem Lett, 24 (3): 821-7. [PMID:24418773]

How to cite this page

S1: Chymotrypsin: protein C, inactivator of coagulation factors Va and VIIIa. Last modified on 29/01/2016. Accessed on 11/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2396.