compound 12 [PMID: 26238322] [Ligand Id: 13151] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3609360 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140] | ||||||||
| ChEMBL | Displacement of [3H]prazosin from alpha1A adrenoceptor in rat submaxillary gland membrane | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 3921-3923 [PMID:26238322] |
| α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368] | ||||||||
| GtoPdb | - | - | 9.8 | pKi | - | - | - | Bioorg Med Chem Lett (2015) 25: 3921-3 [PMID:26238322] |
| ChEMBL | Antagonist activity at human alpha1B adrenoceptor assessed as inhibition of norepinephrine-induced increase of intracellular calcium level by cell based assay | F | 6.25 | pIC50 | 560 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 3921-3923 [PMID:26238322] |
| α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823] | ||||||||
| ChEMBL | Displacement of [3H]prazosin from alpha1B adrenoceptor in rat liver membranes | B | 9.21 | pKi | 0.61 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 3921-3923 [PMID:26238322] |
| α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100] | ||||||||
| ChEMBL | Binding affinity to human recombinant alpha1D adrenoceptor | B | 7.8 | pKi | 16 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 3921-3923 [PMID:26238322] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
