ChEMBL ligand: CHEMBL15848
Fatty acid amide hydrolase/Anandamide amidohydrolase in Human [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612] There should be some charts here, you may need to enable JavaScript!
CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] CB1 receptor/Cannabinoid CB1 receptor in Mouse [ChEMBL: CHEMBL3037] [GtoPdb: 56] [UniProtKB: P47746] CB1 receptor/Cannabinoid CB1 receptor in Rat [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272] There should be some charts here, you may need to enable JavaScript!
CB2 receptor/Cannabinoid CB2 receptor in Human [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] CB2 receptor/Cannabinoid CB2 receptor in Mouse [ChEMBL: CHEMBL5373] [GtoPdb: 57] [UniProtKB: P47936] CB2 receptor/Cannabinoid CB2 receptor in Rat [ChEMBL: CHEMBL2470] [GtoPdb: 57] [UniProtKB: Q9QZN9] There should be some charts here, you may need to enable JavaScript!
Potassium channel subfamily K member 2 in Bovine [ChEMBL: CHEMBL1075183] [UniProtKB: Q8HY88] There should be some charts here, you may need to enable JavaScript!
K2P3.1/Potassium channel subfamily K member 3 in Human [ChEMBL: CHEMBL2321613] [GtoPdb: 515] [UniProtKB: O14649] There should be some charts here, you may need to enable JavaScript!
TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2] There should be some charts here, you may need to enable JavaScript!
TRPV1/Vanilloid receptor in Human [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1] TRPV1/Vanilloid receptor in Rat [ChEMBL: CHEMBL5102] [GtoPdb: 507] [UniProtKB: O35433] There should be some charts here, you may need to enable JavaScript!
GPR18 in Human [GtoPdb: 89] [UniProtKB: Q14330] There should be some charts here, you may need to enable JavaScript!
GPR55 in Human [GtoPdb: 109] [UniProtKB: Q9Y2T6] There should be some charts here, you may need to enable JavaScript!
glycine receptor α1 subunit in Human [GtoPdb: 423] [UniProtKB: P23415] There should be some charts here, you may need to enable JavaScript!
Cav3.1 in Human [GtoPdb: 535] [UniProtKB: O43497] There should be some charts here, you may need to enable JavaScript!
Cav3.2 in Human [GtoPdb: 536] [UniProtKB: O95180] There should be some charts here, you may need to enable JavaScript!
Cav3.3 in Human [GtoPdb: 537] [UniProtKB: Q9P0X4] There should be some charts here, you may need to enable JavaScript!
Kv1.2 in Human [GtoPdb: 539] [UniProtKB: P16389] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519]
ChEMBL	Inhibition of Fatty-acid amide hydrolase (FAAH) activity in human lymphoma U937 cell using [3H]AEA as substrate in the 0-25 uM conc	B	5	pKi	>10000	nM	Ki	J. Med. Chem. (2002) 45: 3709-3720 [PMID:12166944]
ChEMBL	Inhibition of FAAH (unknown origin)	B	5.39	pIC50	4100	nM	IC50	J Med Chem (2018) 61: 5569-5579 [PMID:29856219]
ChEMBL	Inhibition of FAAH	B	5.47	pIC50	3400	nM	IC50	J. Med. Chem. (2008) 51: 7327-7343 [PMID:18983142]
Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612]
ChEMBL	Binding affinity towards Fatty-acid amide hydrolase (FAAH) in rat forebrain membranes	B	5.52	pKi	3000	nM	Ki	Bioorg. Med. Chem. Lett. (2003) 13: 1977-1980 [PMID:12781177]
ChEMBL	Inhibition of rat recombinant FAAH-mediated hydrolysis of [3H]AEA	B	4.93	pIC50	11748.98	nM	IC50	J. Med. Chem. (2009) 52: 4613-4622 [PMID:19719235]
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL	Binding affinity towards cloned human Cannabinoid receptor 1	B	1.95	pKi	1.95	nM	Log Ki	J. Med. Chem. (2000) 43: 2300-2309 [PMID:10882356]
ChEMBL	Ability to displace [3H]CP-55940 from the membranes prepared from HEK cell line with F3.25 (190)A mutant Cannabinoid receptor 1	B	5.74	pKi	1800	nM	Ki	J. Med. Chem. (2003) 46: 5139-5152 [PMID:14613317]
ChEMBL	Ability to displace [3H]CP-55940 from the membranes prepared from HEK cell line with F3.36 (201)A mutant Cannabinoid receptor 1	B	6.52	pKi	300	nM	Ki	J. Med. Chem. (2003) 46: 5139-5152 [PMID:14613317]
ChEMBL	Ability to displace [3H]CP-55940 from the membranes prepared from HEK cell line with W5 43(280)A mutant Cannabinoid receptor 1 at 5 uM	B	6.52	pKi	300	nM	Ki	J. Med. Chem. (2003) 46: 5139-5152 [PMID:14613317]
ChEMBL	Ability to displace [3H]CP-55940 from the membranes prepared from HEK cell line with W6 48(357)A mutant in Cannabinoid receptor 1	B	6.52	pKi	300	nM	Ki	J. Med. Chem. (2003) 46: 5139-5152 [PMID:14613317]
ChEMBL	Ability to displace [3H]CP-55940 from the membranes prepared from HEK cell line with wild type Cannabinoid receptor 1	B	6.52	pKi	300	nM	Ki	J. Med. Chem. (2003) 46: 5139-5152 [PMID:14613317]
GtoPdb	-	-	7	pKi	-	-	-	Mol Pharmacol (1995) 48: 443-50 [PMID:7565624]; J Pharmacol Exp Ther (1996) 278: 989-99 [PMID:8819477]
ChEMBL	Binding affinity to human CB1 receptor in presence of serine protease inhibitor PMSF	B	7.05	pKi	89	nM	Ki	J. Med. Chem. (2013) 56: 8224-8256 [PMID:23865723]
ChEMBL	Binding affinity to CB1 receptor (unknown origin)	B	7.05	pKi	89	nM	Ki	Bioorg Med Chem (2016) 24: 5291-5301 [PMID:27624523]
ChEMBL	Displacement of [3H]-CP55940 from human recombinant CB1 receptor expressed in HEK cell membrane	B	7.14	pKi	72	nM	Ki	Bioorg Med Chem (2020) 28: 115513-115513 [PMID:32340793]
ChEMBL	Displacement of [3H]CP-55940 from human recombinant CB1 receptor	B	7.14	pKi	72	nM	Ki	Bioorg. Med. Chem. Lett. (2006) 16: 138-141 [PMID:16213718]
ChEMBL	Displacement of [3H]CP-55940 from human CB1 receptor expressed in COS cells	B	7.14	pKi	72	nM	Ki	J. Med. Chem. (2005) 48: 7343-7350 [PMID:16279794]
ChEMBL	Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK cells	B	7.14	pKi	72	nM	Ki	Bioorg. Med. Chem. (2007) 15: 5406-5416 [PMID:17561406]
ChEMBL	Binding affinity to human recombinant CB1 receptor expressed in african green monkey COS cells by radioligand binding assay	B	7.14	pKi	72	nM	Ki	J. Med. Chem. (2009) 52: 2506-2514 [PMID:19331413]
ChEMBL	Displacement of [3H]CP-55,940 from human recombinant CB1 receptor expressed in HEK293 cell membranes	B	7.14	pKi	72	nM	Ki	Bioorg. Med. Chem. (2014) 22: 4770-4783 [PMID:25065940]
ChEMBL	Displacement of [3H]CP-55-940 from human recombinant CB1 receptor expressed in COS cells	B	7.15	pKi	70	nM	Ki	J. Med. Chem. (2009) 52: 1005-1017 [PMID:19161308]
ChEMBL	Displacement of [3H]CP55940 from human CB1 receptor expressed in human HEK293 cells in presence of 100 nM PMSF	B	7.15	pKi	70	nM	Ki	J. Med. Chem. (2011) 54: 8278-8288 [PMID:22044209]
ChEMBL	Binding affinity to human recombinant CB1 receptor expressed in COS cells	B	7.15	pKi	70	nM	Ki	J. Med. Chem. (2006) 49: 2333-2338 [PMID:16570929]
ChEMBL	Displacement of [3H]CP-55-940 from human recombinant CB1 receptor in COS cells	B	7.15	pKi	70	nM	Ki	Bioorg. Med. Chem. Lett. (2006) 16: 3765-3768 [PMID:16682198]
ChEMBL	Binding affinity for human cannabinoid receptor 1	B	7.3	pKi	50	nM	Ki	J. Med. Chem. (2005) 48: 5059-5087 [PMID:16078824]
ChEMBL	Binding affinity to CB1R (unknown origin)	B	7.3	pKi	50	nM	Ki	J Med Chem (2017) 60: 4-46 [PMID:27766867]
ChEMBL	Compound was evaluated for its binding affinity towards Cannabinoid receptor 1 [Inactive form(R) of CB1 receptor]	B	7.41	pKi	39.2	nM	Ki	J. Med. Chem. (2002) 45: 3649-3659 [PMID:12166938]
ChEMBL	Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK293 cell membrane	B	7.96	pKi	11	nM	Ki	J. Med. Chem. (2009) 52: 3001-3009 [PMID:19361197]
CB1 receptor/Cannabinoid CB1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3037] [GtoPdb: 56] [UniProtKB: P47746]
ChEMBL	Binding affinity for Cannabinoid receptor 1 in absence of phenylmethylsulfonyl fluoride (PMSF)	B	5.27	pKi	5400	nM	Ki	J. Med. Chem. (1997) 40: 3617-3625 [PMID:9357528]
ChEMBL	Binding affinity for Cannabinoid receptor 1 in presence of phenylmethylsulfonyl fluoride (PMSF)	B	7.05	pKi	89	nM	Ki	J. Med. Chem. (1997) 40: 3617-3625 [PMID:9357528]
ChEMBL	Binding affinity towards Cannabinoid receptor 1 was determined using [3H]-CP- cannabinoid as radioligand with mouse brain membrane	B	4.92	pIC50	12000	nM	IC50	Bioorg. Med. Chem. Lett. (2003) 13: 3301-3303 [PMID:12951114]
ChEMBL	Binding affinity towards Cannabinoid receptor 1 was determined using [3H]-CP- cannabinoid as radioligand with mouse brain membrane in the presence of PMSF	B	7.41	pIC50	39	nM	IC50	Bioorg. Med. Chem. Lett. (2003) 13: 3301-3303 [PMID:12951114]
ChEMBL	Agonist activity at CB1 receptor expressed in mouse brain membrane by [35S]GTPgammaS binding assay	F	6.44	pEC50	360	nM	EC50	J. Med. Chem. (2009) 52: 3001-3009 [PMID:19361197]
CB1 receptor/Cannabinoid CB1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272]
ChEMBL	Binding affinity towards cannabinoid receptor 1 from rat forebrain membranes in the absence of phenylmethanesulfonylfluoride (PMSF) using 0.8 nM [3H]CP-55940 as radioligand	B	5.24	pKi	5810	nM	Ki	J. Med. Chem. (1998) 41: 5353-5361 [PMID:9876105]
ChEMBL	The compound was tested for Ki value against rat whole brain P2 membrane preparation in absence of enzyme inhibitor PMSF	B	5.27	pKi	5400	nM	Ki	J. Med. Chem. (1999) 42: 1975-1981 [PMID:10354405]
ChEMBL	Displacement of [3H]CP-55,940 from CB1 receptor in rat brain membranes in absence of FAAH inhibitor PMSF by radioligand binding assay	B	6	pKi	>1000	nM	Ki	J Med Chem (2018) 61: 8639-8657 [PMID:30196704]
ChEMBL	Concentration required to displace 0.4 nM [3H]SR-141,716A from CB1 receptor in rat brain preparations in the presence of 0.1 mM phenylmethyl sulfonyl fluoride	B	6.1	pKi	800	nM	Ki	Bioorg. Med. Chem. Lett. (2001) 11: 447-449 [PMID:11229744]
ChEMBL	Displacement of [3H]SR141716A from CB1 receptor in CD rat brain membranes	B	6.4	pKi	400	nM	Ki	J. Nat. Prod. (2003) 66: 1364-1368 [PMID:14575438]
ChEMBL	Binding affinity to CB1 cannabinoid receptor using [3H]WIN-55212-2 in rat cerebellum membranes	B	6.55	pKi	285	nM	Ki	J. Med. Chem. (2001) 44: 4505-4508 [PMID:11741470]
ChEMBL	Displacement of [3H]SR141716A from CB1 receptor in rat cerebellar membrane after 90 mins by scintillation counting	B	6.88	pKi	132	nM	Ki	Eur. J. Med. Chem. (2009) 44: 4889-4895 [PMID:19762126]
ChEMBL	Displacement of [3H]CP-55940 from rat forebrain membrane which expresses Cannabinoid receptor 1 in the presence of PMSF	B	7.05	pKi	90	nM	Ki	J. Med. Chem. (2002) 45: 3709-3720 [PMID:12166944]
ChEMBL	Binding affinity towards Cannabinoid receptor 1 in rat forebrain membranes using [3H]CP-55940 as radioligand	B	7.05	pKi	90	nM	Ki	Bioorg. Med. Chem. Lett. (2003) 13: 1977-1980 [PMID:12781177]
ChEMBL	The compound was tested for Ki value against rat whole brain P2 membrane preparation in presence of enzyme inhibitor PMSF.	B	7.05	pKi	89	nM	Ki	J. Med. Chem. (1999) 42: 1975-1981 [PMID:10354405]
ChEMBL	Displacement of [3H]CP55940 from CB1 receptor in Wistar rat brain incubated for 60 mins by radioactive filter binding assay	B	7.05	pKi	89	nM	Ki	Eur. J. Med. Chem. (2016) 112: 66-80 [PMID:26890113]
ChEMBL	Displacement of [3H]CP-55940 from Cannabinoid receptor 1 of rat forebrain membranes	B	7.11	pKi	78	nM	Ki	J. Med. Chem. (1996) 39: 4515-4519 [PMID:8893848]
ChEMBL	Tested for binding affinity to Cannabinoid receptor 1	B	7.11	pKi	78	nM	Ki	J. Med. Chem. (1999) 42: 896-902 [PMID:10072686]
ChEMBL	Displacement of [3H]CP-55,940 from CB1 receptor in rat brain membranes in presence of FAAH inhibitor PMSF by radioligand binding assay	B	7.13	pKi	74	nM	Ki	J Med Chem (2018) 61: 8639-8657 [PMID:30196704]
ChEMBL	Binding affinity for cannabinoid receptor 1	B	7.14	pKi	72	nM	Ki	J. Med. Chem. (2005) 48: 5059-5087 [PMID:16078824]
ChEMBL	Binding affinity towards cannabinoid receptor 1 from rat forebrain membranes in the presence of phenylmethanesulfonylfluoride (PMSF) using 0.8 nM [3H]CP-55940 as radioligand	B	7.21	pKi	61	nM	Ki	J. Med. Chem. (1998) 41: 5353-5361 [PMID:9876105]
ChEMBL	In vitro binding affinity was determined against rat brain Cannabinoid receptor 1	B	7.41	pKi	39.2	nM	Ki	J. Med. Chem. (1997) 40: 659-667 [PMID:9057852]
ChEMBL	Displacement of [3H]CP-55940 binding to Cannabinoid receptor 1 in rat brain membranes	B	7.66	pKi	22	nM	Ki	J. Med. Chem. (1998) 41: 4207-4215 [PMID:9784095]
ChEMBL	Binding affinity towards Cannabinoid receptor 1 was determined using [3H]-CP- cannabinoid as radioligand with rat brain membrane in the presence of PMSF	B	7.4	pIC50	40	nM	IC50	Bioorg. Med. Chem. Lett. (2003) 13: 3301-3303 [PMID:12951114]
ChEMBL	Cannabinoid receptor 1 dependent activity of compound was evaluated by using [35S]GTP-gamma-S-binding studies	F	4.8	pEC50	15848.93	nM	EC50	Bioorg. Med. Chem. Lett. (2004) 14: 3231-3234 [PMID:15149681]
ChEMBL	Displacement of [35S]GTP-gamma-S from rat cerebellar CB1 receptor	F	4.8	pEC50	15848.93	nM	EC50	J. Med. Chem. (2006) 49: 554-566 [PMID:16420041]
ChEMBL	Agonist activity at rat CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins	F	7.16	pEC50	69	nM	EC50	J Med Chem (2018) 61: 8639-8657 [PMID:30196704]
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
ChEMBL	Binding affinity towards cloned human cannabinoid receptor 2	B	2.57	pKi	2.57	nM	Log Ki	J. Med. Chem. (2000) 43: 2300-2309 [PMID:10882356]
ChEMBL	Binding affinity to human CB2 cannabinoid receptor using [3H]CP-55940 in HEK293 EBNA transfected cells	B	6	pKi	>1000	nM	Ki	J. Med. Chem. (2001) 44: 4505-4508 [PMID:11741470]
GtoPdb	-	-	6.4	pKi	-	-	-	Mol Pharmacol (1995) 48: 443-50 [PMID:7565624]; J Pharmacol Exp Ther (1996) 278: 989-99 [PMID:8819477]; Biochem Pharmacol (1995) 50: 83-90 [PMID:7605349]
ChEMBL	Binding affinity to CB2 receptor (unknown origin)	B	6.43	pKi	371	nM	Ki	Bioorg Med Chem (2016) 24: 5291-5301 [PMID:27624523]
ChEMBL	Binding affinity to human CB2 receptor in presence of serine protease inhibitor PMSF	B	6.43	pKi	371	nM	Ki	J. Med. Chem. (2013) 56: 8224-8256 [PMID:23865723]
ChEMBL	Displacement of [3H]CP-55-940 from human recombinant CB2 receptor in COS cells	B	6.74	pKi	180	nM	Ki	Bioorg. Med. Chem. Lett. (2006) 16: 3765-3768 [PMID:16682198]
ChEMBL	Displacement of [3H]CP-55-940 from human recombinant CB2 receptor expressed in COS cells	B	6.74	pKi	180	nM	Ki	J. Med. Chem. (2009) 52: 1005-1017 [PMID:19161308]
ChEMBL	Displacement of [3H]CP-55940 from human recombinant CB2 receptor	B	6.74	pKi	180	nM	Ki	Bioorg. Med. Chem. Lett. (2006) 16: 138-141 [PMID:16213718]
ChEMBL	Binding affinity to human recombinant CB2 receptor expressed in COS cells	B	6.74	pKi	180	nM	Ki	J. Med. Chem. (2006) 49: 2333-2338 [PMID:16570929]
ChEMBL	Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK293 cell membrane	B	6.77	pKi	168	nM	Ki	J. Med. Chem. (2009) 52: 3001-3009 [PMID:19361197]
ChEMBL	Displacement of [3H]CP-55,940 from human CB2 receptor expressed in HEK293 cell membranes in absence of FAAH inhibitor PMSF by radioligand binding assay	B	6.8	pKi	160	nM	Ki	J Med Chem (2018) 61: 8639-8657 [PMID:30196704]
CB2 receptor/Cannabinoid CB2 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5373] [GtoPdb: 57] [UniProtKB: P47936]
ChEMBL	Binding affinity towards Cannabinoid receptor 2 from mouse spleen membranes using 0.8 nM [3H]CP-55940 as radioligand	B	5.71	pKi	1930	nM	Ki	J. Med. Chem. (1998) 41: 5353-5361 [PMID:9876105]
ChEMBL	Compound was evaluated for its binding affinity for mouse spleen Cannabinoid receptor 2	B	5.72	pKi	1926	nM	Ki	J. Med. Chem. (1996) 39: 4515-4519 [PMID:8893848]
ChEMBL	Displacement of [3H]CP-55,940 from mouse CB2 receptor expressed in HEK293 cell membranes in absence of FAAH inhibitor PMSF by radioligand binding assay	B	6	pKi	>1000	nM	Ki	J Med Chem (2018) 61: 8639-8657 [PMID:30196704]
CB2 receptor/Cannabinoid CB2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2470] [GtoPdb: 57] [UniProtKB: Q9QZN9]
ChEMBL	Displacement of [3H]CP-55940 from rat forebrain membrane which expresses Cannabinoid receptor 2 in the presence of PMSF	B	6.44	pKi	360	nM	Ki	J. Med. Chem. (2002) 45: 3709-3720 [PMID:12166944]
Potassium channel subfamily K member 2 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075183] [UniProtKB: Q8HY88]
ChEMBL	Activation of bovine TREK1 expressed in AZT cells assessed as reduction in channel currents	B	6	pIC50	1000	nM	IC50	J. Med. Chem. (2016) 59: 5149-5157 [PMID:26588045]
K2P3.1/Potassium channel subfamily K member 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2321613] [GtoPdb: 515] [UniProtKB: O14649]
ChEMBL	Inhibition of human TASK1 expressed in African green monkey COS7 cells by whole cell patch clamp assay	B	5.52	pIC50	3000	nM	IC50	J Med Chem (2019) 62: 10044-10058 [PMID:31260312]
GtoPdb	-	-	5.6	pIC50	2700	nM	IC50	EMBO J (2001) 20: 47-54 [PMID:11226154]
GtoPdb	-	-	6.15	pIC50	~700	nM	IC50	EMBO J (2001) 20: 47-54 [PMID:11226154]
TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2]
ChEMBL	Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry	B	5.07	pIC50	8600	nM	IC50	J Med Chem (2018) 61: 8255-8281 [PMID:30176215]
ChEMBL	Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry	B	6.02	pIC50	960	nM	IC50	J Med Chem (2018) 61: 8255-8281 [PMID:30176215]
TRPV1/Vanilloid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1]
GtoPdb	-	-	5	pEC50	-	-	-	J Biol Chem (2003) 278: 30429-34 [PMID:12761211]
GtoPdb	-	-	5.9	pEC50	-	-	-	Br J Pharmacol (2000) 129: 227-30 [PMID:10694225]
ChEMBL	Activation of human VR1 expressed in HEK293 cells assessed as stimulation of Ca2+ influx	B	6.2	pEC50	630	nM	EC50	J. Med. Chem. (2013) 56: 8224-8256 [PMID:23865723]
ChEMBL	Agonist activity on human recombinant TRPV1-mediated enhancement of intracellular calcium concentration in HEK293 cells	F	6.31	pEC50	490	nM	EC50	J. Med. Chem. (2006) 49: 2333-2338 [PMID:16570929]
ChEMBL	Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level	F	6.7	pEC50	200	nM	EC50	J. Med. Chem. (2009) 52: 3001-3009 [PMID:19361197]
ChEMBL	Agonist activity at TRPV1 receptor (unknown origin)	B	7.8	pEC50	15.8	nM	EC50	J. Med. Chem. (2013) 56: 1811-1829 [PMID:23384387]
TRPV1/Vanilloid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5102] [GtoPdb: 507] [UniProtKB: O35433]
ChEMBL	Binding affinity to vanilloid VR1 receptor using [3H]resiniferatoxin ([3H]-RTX) in rat spinal cord membranes	B	6.77	pKi	169	nM	Ki	J. Med. Chem. (2001) 44: 4505-4508 [PMID:11741470]
GtoPdb	-	-	5.3	pEC50	-	-	-	Nature (1999) 400: 452-7 [PMID:10440374]
GPR18 in Human [GtoPdb: 89] [UniProtKB: Q14330]
GtoPdb	-	-	5.42	pEC50	3830	nM	EC50	Br J Pharmacol (2012) 165: 2414-24 [PMID:21595653]
GPR55 in Human [GtoPdb: 109] [UniProtKB: Q9Y2T6]
GtoPdb	-	-	7.74	pEC50	18	nM	EC50	Br J Pharmacol (2007) 152: 1092-101 [PMID:17876302]
glycine receptor α1 subunit in Human [GtoPdb: 423] [UniProtKB: P23415]
GtoPdb	-	-	7.4	pEC50	38	nM	EC50
Cav3.1 in Human [GtoPdb: 535] [UniProtKB: O43497]
GtoPdb	-	-	5.4	pIC50	-	-	-	EMBO J (2001) 20: 7033-40 [PMID:11742980]
Cav3.2 in Human [GtoPdb: 536] [UniProtKB: O95180]
GtoPdb	-	-	6.5	pIC50	-	-	-	EMBO J (2001) 20: 7033-40 [PMID:11742980]
Cav3.3 in Human [GtoPdb: 537] [UniProtKB: Q9P0X4]
GtoPdb	-	-	6	pIC50	-	-	-	EMBO J (2001) 20: 7033-40 [PMID:11742980]
Kv1.2 in Human [GtoPdb: 539] [UniProtKB: P16389]
GtoPdb	-	-	5.6	pIC50	2700	nM	IC50	Neuropharmacology (1996) 35: 983-91 [PMID:8938728]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]