anandamide [Ligand Id: 2364] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL15848 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] | ||||||||
| ChEMBL | Inhibition of Fatty-acid amide hydrolase (FAAH) activity in human lymphoma U937 cell using [3H]AEA as substrate in the 0-25 uM conc | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2002) 45: 3709-3720 [PMID:12166944] |
| ChEMBL | Inhibition of FAAH (unknown origin) | B | 5.39 | pIC50 | 4100 | nM | IC50 | J Med Chem (2018) 61: 5569-5579 [PMID:29856219] |
| ChEMBL | Inhibition of FAAH | B | 5.47 | pIC50 | 3400 | nM | IC50 | J Med Chem (2008) 51: 7327-7343 [PMID:18983142] |
| Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612] | ||||||||
| ChEMBL | Binding affinity towards Fatty-acid amide hydrolase (FAAH) in rat forebrain membranes | B | 5.52 | pKi | 3000 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1977-1980 [PMID:12781177] |
| ChEMBL | Inhibition of rat recombinant FAAH-mediated hydrolysis of [3H]AEA | B | 4.93 | pIC50 | 11748.98 | nM | IC50 | J Med Chem (2009) 52: 4613-4622 [PMID:19719235] |
| CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
| ChEMBL | Binding affinity towards cloned human Cannabinoid receptor 1 | B | 1.95 | pKi | 1.95 | nM | Log Ki | J Med Chem (2000) 43: 2300-2309 [PMID:10882356] |
| ChEMBL | Ability to displace [3H]CP-55940 from the membranes prepared from HEK cell line with F3.25 (190)A mutant Cannabinoid receptor 1 | B | 5.74 | pKi | 1800 | nM | Ki | J Med Chem (2003) 46: 5139-5152 [PMID:14613317] |
| ChEMBL | Ability to displace [3H]CP-55940 from the membranes prepared from HEK cell line with F3.36 (201)A mutant Cannabinoid receptor 1 | B | 6.52 | pKi | 300 | nM | Ki | J Med Chem (2003) 46: 5139-5152 [PMID:14613317] |
| ChEMBL | Ability to displace [3H]CP-55940 from the membranes prepared from HEK cell line with W5 43(280)A mutant Cannabinoid receptor 1 at 5 uM | B | 6.52 | pKi | 300 | nM | Ki | J Med Chem (2003) 46: 5139-5152 [PMID:14613317] |
| ChEMBL | Ability to displace [3H]CP-55940 from the membranes prepared from HEK cell line with W6 48(357)A mutant in Cannabinoid receptor 1 | B | 6.52 | pKi | 300 | nM | Ki | J Med Chem (2003) 46: 5139-5152 [PMID:14613317] |
| ChEMBL | Ability to displace [3H]CP-55940 from the membranes prepared from HEK cell line with wild type Cannabinoid receptor 1 | B | 6.52 | pKi | 300 | nM | Ki | J Med Chem (2003) 46: 5139-5152 [PMID:14613317] |
| GtoPdb | - | - | 7 | pKi | - | - | - |
Mol Pharmacol (1995) 48: 443-50 [PMID:7565624]; J Pharmacol Exp Ther (1996) 278: 989-99 [PMID:8819477] |
| ChEMBL | Binding affinity to human CB1 receptor in presence of serine protease inhibitor PMSF | B | 7.05 | pKi | 89 | nM | Ki | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
| ChEMBL | Binding affinity to CB1 receptor (unknown origin) | B | 7.05 | pKi | 89 | nM | Ki | Bioorg Med Chem (2016) 24: 5291-5301 [PMID:27624523] |
| ChEMBL | Displacement of [3H]-CP55940 from human recombinant CB1 receptor expressed in HEK cell membrane | B | 7.14 | pKi | 72 | nM | Ki | Bioorg Med Chem (2020) 28: 115513-115513 [PMID:32340793] |
| ChEMBL | Displacement of [3H]CP-55940 from human recombinant CB1 receptor | B | 7.14 | pKi | 72 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 138-141 [PMID:16213718] |
| ChEMBL | Displacement of [3H]CP-55940 from human CB1 receptor expressed in COS cells | B | 7.14 | pKi | 72 | nM | Ki | J Med Chem (2005) 48: 7343-7350 [PMID:16279794] |
| ChEMBL | Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK cells | B | 7.14 | pKi | 72 | nM | Ki | Bioorg Med Chem (2007) 15: 5406-5416 [PMID:17561406] |
| ChEMBL | Binding affinity to human recombinant CB1 receptor expressed in african green monkey COS cells by radioligand binding assay | B | 7.14 | pKi | 72 | nM | Ki | J Med Chem (2009) 52: 2506-2514 [PMID:19331413] |
| ChEMBL | Displacement of [3H]CP-55,940 from human recombinant CB1 receptor expressed in HEK293 cell membranes | B | 7.14 | pKi | 72 | nM | Ki | Bioorg Med Chem (2014) 22: 4770-4783 [PMID:25065940] |
| ChEMBL | Displacement of [3H]CP-55-940 from human recombinant CB1 receptor expressed in COS cells | B | 7.15 | pKi | 70 | nM | Ki | J Med Chem (2009) 52: 1005-1017 [PMID:19161308] |
| ChEMBL | Displacement of [3H]CP55940 from human CB1 receptor expressed in human HEK293 cells in presence of 100 nM PMSF | B | 7.15 | pKi | 70 | nM | Ki | J Med Chem (2011) 54: 8278-8288 [PMID:22044209] |
| ChEMBL | Binding affinity to human recombinant CB1 receptor expressed in COS cells | B | 7.15 | pKi | 70 | nM | Ki | J Med Chem (2006) 49: 2333-2338 [PMID:16570929] |
| ChEMBL | Displacement of [3H]CP-55-940 from human recombinant CB1 receptor in COS cells | B | 7.15 | pKi | 70 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 3765-3768 [PMID:16682198] |
| ChEMBL | Binding affinity for human cannabinoid receptor 1 | B | 7.3 | pKi | 50 | nM | Ki | J Med Chem (2005) 48: 5059-5087 [PMID:16078824] |
| ChEMBL | Binding affinity to CB1R (unknown origin) | B | 7.3 | pKi | 50 | nM | Ki | J Med Chem (2017) 60: 4-46 [PMID:27766867] |
| ChEMBL | Compound was evaluated for its binding affinity towards Cannabinoid receptor 1 [Inactive form(R) of CB1 receptor] | B | 7.41 | pKi | 39.2 | nM | Ki | J Med Chem (2002) 45: 3649-3659 [PMID:12166938] |
| ChEMBL | Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK293 cell membrane | B | 7.96 | pKi | 11 | nM | Ki | J Med Chem (2009) 52: 3001-3009 [PMID:19361197] |
| CB1 receptor/Cannabinoid CB1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3037] [GtoPdb: 56] [UniProtKB: P47746] | ||||||||
| ChEMBL | Binding affinity for Cannabinoid receptor 1 in absence of phenylmethylsulfonyl fluoride (PMSF) | B | 5.27 | pKi | 5400 | nM | Ki | J Med Chem (1997) 40: 3617-3625 [PMID:9357528] |
| ChEMBL | Binding affinity for Cannabinoid receptor 1 in presence of phenylmethylsulfonyl fluoride (PMSF) | B | 7.05 | pKi | 89 | nM | Ki | J Med Chem (1997) 40: 3617-3625 [PMID:9357528] |
| ChEMBL | Binding affinity towards Cannabinoid receptor 1 was determined using [3H]-CP- cannabinoid as radioligand with mouse brain membrane | B | 4.92 | pIC50 | 12000 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 3301-3303 [PMID:12951114] |
| ChEMBL | Binding affinity towards Cannabinoid receptor 1 was determined using [3H]-CP- cannabinoid as radioligand with mouse brain membrane in the presence of PMSF | B | 7.41 | pIC50 | 39 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 3301-3303 [PMID:12951114] |
| ChEMBL | Agonist activity at CB1 receptor expressed in mouse brain membrane by [35S]GTPgammaS binding assay | F | 6.44 | pEC50 | 360 | nM | EC50 | J Med Chem (2009) 52: 3001-3009 [PMID:19361197] |
| CB1 receptor/Cannabinoid CB1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272] | ||||||||
| ChEMBL | Binding affinity towards cannabinoid receptor 1 from rat forebrain membranes in the absence of phenylmethanesulfonylfluoride (PMSF) using 0.8 nM [3H]CP-55940 as radioligand | B | 5.24 | pKi | 5810 | nM | Ki | J Med Chem (1998) 41: 5353-5361 [PMID:9876105] |
| ChEMBL | The compound was tested for Ki value against rat whole brain P2 membrane preparation in absence of enzyme inhibitor PMSF | B | 5.27 | pKi | 5400 | nM | Ki | J Med Chem (1999) 42: 1975-1981 [PMID:10354405] |
| ChEMBL | Displacement of [3H]CP-55,940 from CB1 receptor in rat brain membranes in absence of FAAH inhibitor PMSF by radioligand binding assay | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2018) 61: 8639-8657 [PMID:30196704] |
| ChEMBL | Concentration required to displace 0.4 nM [3H]SR-141,716A from CB1 receptor in rat brain preparations in the presence of 0.1 mM phenylmethyl sulfonyl fluoride | B | 6.1 | pKi | 800 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 447-449 [PMID:11229744] |
| ChEMBL | Displacement of [3H]SR141716A from CB1 receptor in CD rat brain membranes | B | 6.4 | pKi | 400 | nM | Ki | J Nat Prod (2003) 66: 1364-1368 [PMID:14575438] |
| ChEMBL | Binding affinity to CB1 cannabinoid receptor using [3H]WIN-55212-2 in rat cerebellum membranes | B | 6.55 | pKi | 285 | nM | Ki | J Med Chem (2001) 44: 4505-4508 [PMID:11741470] |
| ChEMBL | Displacement of [3H]SR141716A from CB1 receptor in rat cerebellar membrane after 90 mins by scintillation counting | B | 6.88 | pKi | 132 | nM | Ki | Eur J Med Chem (2009) 44: 4889-4895 [PMID:19762126] |
| ChEMBL | Displacement of [3H]CP-55940 from rat forebrain membrane which expresses Cannabinoid receptor 1 in the presence of PMSF | B | 7.05 | pKi | 90 | nM | Ki | J Med Chem (2002) 45: 3709-3720 [PMID:12166944] |
| ChEMBL | Binding affinity towards Cannabinoid receptor 1 in rat forebrain membranes using [3H]CP-55940 as radioligand | B | 7.05 | pKi | 90 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1977-1980 [PMID:12781177] |
| ChEMBL | The compound was tested for Ki value against rat whole brain P2 membrane preparation in presence of enzyme inhibitor PMSF. | B | 7.05 | pKi | 89 | nM | Ki | J Med Chem (1999) 42: 1975-1981 [PMID:10354405] |
| ChEMBL | Displacement of [3H]CP55940 from CB1 receptor in Wistar rat brain incubated for 60 mins by radioactive filter binding assay | B | 7.05 | pKi | 89 | nM | Ki | Eur J Med Chem (2016) 112: 66-80 [PMID:26890113] |
| ChEMBL | Displacement of [3H]CP-55940 from Cannabinoid receptor 1 of rat forebrain membranes | B | 7.11 | pKi | 78 | nM | Ki | J Med Chem (1996) 39: 4515-4519 [PMID:8893848] |
| ChEMBL | Tested for binding affinity to Cannabinoid receptor 1 | B | 7.11 | pKi | 78 | nM | Ki | J Med Chem (1999) 42: 896-902 [PMID:10072686] |
| ChEMBL | Displacement of [3H]CP-55,940 from CB1 receptor in rat brain membranes in presence of FAAH inhibitor PMSF by radioligand binding assay | B | 7.13 | pKi | 74 | nM | Ki | J Med Chem (2018) 61: 8639-8657 [PMID:30196704] |
| ChEMBL | Binding affinity for cannabinoid receptor 1 | B | 7.14 | pKi | 72 | nM | Ki | J Med Chem (2005) 48: 5059-5087 [PMID:16078824] |
| ChEMBL | Binding affinity towards cannabinoid receptor 1 from rat forebrain membranes in the presence of phenylmethanesulfonylfluoride (PMSF) using 0.8 nM [3H]CP-55940 as radioligand | B | 7.21 | pKi | 61 | nM | Ki | J Med Chem (1998) 41: 5353-5361 [PMID:9876105] |
| ChEMBL | In vitro binding affinity was determined against rat brain Cannabinoid receptor 1 | B | 7.41 | pKi | 39.2 | nM | Ki | J Med Chem (1997) 40: 659-667 [PMID:9057852] |
| ChEMBL | Displacement of [3H]CP-55940 binding to Cannabinoid receptor 1 in rat brain membranes | B | 7.66 | pKi | 22 | nM | Ki | J Med Chem (1998) 41: 4207-4215 [PMID:9784095] |
| ChEMBL | Binding affinity towards Cannabinoid receptor 1 was determined using [3H]-CP- cannabinoid as radioligand with rat brain membrane in the presence of PMSF | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 3301-3303 [PMID:12951114] |
| ChEMBL | Cannabinoid receptor 1 dependent activity of compound was evaluated by using [35S]GTP-gamma-S-binding studies | F | 4.8 | pEC50 | 15848.93 | nM | EC50 | Bioorg Med Chem Lett (2004) 14: 3231-3234 [PMID:15149681] |
| ChEMBL | Displacement of [35S]GTP-gamma-S from rat cerebellar CB1 receptor | F | 4.8 | pEC50 | 15848.93 | nM | EC50 | J Med Chem (2006) 49: 554-566 [PMID:16420041] |
| ChEMBL | Agonist activity at rat CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins | F | 7.16 | pEC50 | 69 | nM | EC50 | J Med Chem (2018) 61: 8639-8657 [PMID:30196704] |
| CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] | ||||||||
| ChEMBL | Binding affinity towards cloned human cannabinoid receptor 2 | B | 2.57 | pKi | 2.57 | nM | Log Ki | J Med Chem (2000) 43: 2300-2309 [PMID:10882356] |
| ChEMBL | Binding affinity to human CB2 cannabinoid receptor using [3H]CP-55940 in HEK293 EBNA transfected cells | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2001) 44: 4505-4508 [PMID:11741470] |
| GtoPdb | - | - | 6.4 | pKi | - | - | - |
Mol Pharmacol (1995) 48: 443-50 [PMID:7565624]; J Pharmacol Exp Ther (1996) 278: 989-99 [PMID:8819477]; Biochem Pharmacol (1995) 50: 83-90 [PMID:7605349] |
| ChEMBL | Binding affinity to CB2 receptor (unknown origin) | B | 6.43 | pKi | 371 | nM | Ki | Bioorg Med Chem (2016) 24: 5291-5301 [PMID:27624523] |
| ChEMBL | Binding affinity to human CB2 receptor in presence of serine protease inhibitor PMSF | B | 6.43 | pKi | 371 | nM | Ki | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
| ChEMBL | Displacement of [3H]CP-55-940 from human recombinant CB2 receptor in COS cells | B | 6.74 | pKi | 180 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 3765-3768 [PMID:16682198] |
| ChEMBL | Displacement of [3H]CP-55-940 from human recombinant CB2 receptor expressed in COS cells | B | 6.74 | pKi | 180 | nM | Ki | J Med Chem (2009) 52: 1005-1017 [PMID:19161308] |
| ChEMBL | Displacement of [3H]CP-55940 from human recombinant CB2 receptor | B | 6.74 | pKi | 180 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 138-141 [PMID:16213718] |
| ChEMBL | Binding affinity to human recombinant CB2 receptor expressed in COS cells | B | 6.74 | pKi | 180 | nM | Ki | J Med Chem (2006) 49: 2333-2338 [PMID:16570929] |
| ChEMBL | Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK293 cell membrane | B | 6.77 | pKi | 168 | nM | Ki | J Med Chem (2009) 52: 3001-3009 [PMID:19361197] |
| ChEMBL | Displacement of [3H]CP-55,940 from human CB2 receptor expressed in HEK293 cell membranes in absence of FAAH inhibitor PMSF by radioligand binding assay | B | 6.8 | pKi | 160 | nM | Ki | J Med Chem (2018) 61: 8639-8657 [PMID:30196704] |
| CB2 receptor/Cannabinoid CB2 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5373] [GtoPdb: 57] [UniProtKB: P47936] | ||||||||
| ChEMBL | Binding affinity towards Cannabinoid receptor 2 from mouse spleen membranes using 0.8 nM [3H]CP-55940 as radioligand | B | 5.71 | pKi | 1930 | nM | Ki | J Med Chem (1998) 41: 5353-5361 [PMID:9876105] |
| ChEMBL | Compound was evaluated for its binding affinity for mouse spleen Cannabinoid receptor 2 | B | 5.72 | pKi | 1926 | nM | Ki | J Med Chem (1996) 39: 4515-4519 [PMID:8893848] |
| ChEMBL | Displacement of [3H]CP-55,940 from mouse CB2 receptor expressed in HEK293 cell membranes in absence of FAAH inhibitor PMSF by radioligand binding assay | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2018) 61: 8639-8657 [PMID:30196704] |
| CB2 receptor/Cannabinoid CB2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2470] [GtoPdb: 57] [UniProtKB: Q9QZN9] | ||||||||
| ChEMBL | Displacement of [3H]CP-55940 from rat forebrain membrane which expresses Cannabinoid receptor 2 in the presence of PMSF | B | 6.44 | pKi | 360 | nM | Ki | J Med Chem (2002) 45: 3709-3720 [PMID:12166944] |
| Potassium channel subfamily K member 2 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075183] [UniProtKB: Q8HY88] | ||||||||
| ChEMBL | Activation of bovine TREK1 expressed in AZT cells assessed as reduction in channel currents | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (2016) 59: 5149-5157 [PMID:26588045] |
| K2P3.1/Potassium channel subfamily K member 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2321613] [GtoPdb: 515] [UniProtKB: O14649] | ||||||||
| ChEMBL | Inhibition of human TASK1 expressed in African green monkey COS7 cells by whole cell patch clamp assay | B | 5.52 | pIC50 | 3000 | nM | IC50 | J Med Chem (2019) 62: 10044-10058 [PMID:31260312] |
| GtoPdb | - | - | 5.6 | pIC50 | 2700 | nM | IC50 | EMBO J (2001) 20: 47-54 [PMID:11226154] |
| GtoPdb | - | - | 6.15 | pIC50 | ~700 | nM | IC50 | EMBO J (2001) 20: 47-54 [PMID:11226154] |
| TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2] | ||||||||
| ChEMBL | Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry | B | 5.07 | pIC50 | 8600 | nM | IC50 | J Med Chem (2018) 61: 8255-8281 [PMID:30176215] |
| ChEMBL | Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry | B | 6.02 | pIC50 | 960 | nM | IC50 | J Med Chem (2018) 61: 8255-8281 [PMID:30176215] |
| TRPV1/Vanilloid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1] | ||||||||
| GtoPdb | - | - | 5 | pEC50 | - | - | - | J Biol Chem (2003) 278: 30429-34 [PMID:12761211] |
| GtoPdb | - | - | 5.9 | pEC50 | - | - | - | Br J Pharmacol (2000) 129: 227-30 [PMID:10694225] |
| ChEMBL | Activation of human VR1 expressed in HEK293 cells assessed as stimulation of Ca2+ influx | B | 6.2 | pEC50 | 630 | nM | EC50 | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
| ChEMBL | Agonist activity on human recombinant TRPV1-mediated enhancement of intracellular calcium concentration in HEK293 cells | F | 6.31 | pEC50 | 490 | nM | EC50 | J Med Chem (2006) 49: 2333-2338 [PMID:16570929] |
| ChEMBL | Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level | F | 6.7 | pEC50 | 200 | nM | EC50 | J Med Chem (2009) 52: 3001-3009 [PMID:19361197] |
| ChEMBL | Agonist activity at TRPV1 receptor (unknown origin) | B | 7.8 | pEC50 | 15.8 | nM | EC50 | J Med Chem (2013) 56: 1811-1829 [PMID:23384387] |
| TRPV1/Vanilloid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5102] [GtoPdb: 507] [UniProtKB: O35433] | ||||||||
| ChEMBL | Binding affinity to vanilloid VR1 receptor using [3H]resiniferatoxin ([3H]-RTX) in rat spinal cord membranes | B | 6.77 | pKi | 169 | nM | Ki | J Med Chem (2001) 44: 4505-4508 [PMID:11741470] |
| GtoPdb | - | - | 5.3 | pEC50 | - | - | - | Nature (1999) 400: 452-7 [PMID:10440374] |
| GPR18 in Human [GtoPdb: 89] [UniProtKB: Q14330] | ||||||||
| GtoPdb | - | - | 5.42 | pEC50 | 3830 | nM | EC50 | Br J Pharmacol (2012) 165: 2414-24 [PMID:21595653] |
| GPR55 in Human [GtoPdb: 109] [UniProtKB: Q9Y2T6] | ||||||||
| GtoPdb | - | - | 7.74 | pEC50 | 18 | nM | EC50 | Br J Pharmacol (2007) 152: 1092-101 [PMID:17876302] |
| glycine receptor α1 subunit in Human [GtoPdb: 423] [UniProtKB: P23415] | ||||||||
| GtoPdb | - | - | 7.4 | pEC50 | 38 | nM | EC50 | |
| Cav3.1 in Human [GtoPdb: 535] [UniProtKB: O43497] | ||||||||
| GtoPdb | - | - | 5.4 | pIC50 | - | - | - | EMBO J (2001) 20: 7033-40 [PMID:11742980] |
| Cav3.2 in Human [GtoPdb: 536] [UniProtKB: O95180] | ||||||||
| GtoPdb | - | - | 6.5 | pIC50 | - | - | - | EMBO J (2001) 20: 7033-40 [PMID:11742980] |
| Cav3.3 in Human [GtoPdb: 537] [UniProtKB: Q9P0X4] | ||||||||
| GtoPdb | - | - | 6 | pIC50 | - | - | - | EMBO J (2001) 20: 7033-40 [PMID:11742980] |
| Kv1.2 in Human [GtoPdb: 539] [UniProtKB: P16389] | ||||||||
| GtoPdb | - | - | 5.6 | pIC50 | 2700 | nM | IC50 | Neuropharmacology (1996) 35: 983-91 [PMID:8938728] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
