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vorolanib   Click here for help

GtoPdb Ligand ID: 11618

Synonyms: CM-082 | CM082 | Example 8 [WO2008033562A2] | EYP-1901 | X-82
Compound class: Synthetic organic
Comment: Vorolanib (CM082) is a potent and selective, oral clinical stage multi-kinase inhibitor. Targets include all VEGFR isoforms, PDGFR and CSF1R. [1-3]. It is a structural derivative of sunitinib. Vorolanib has anti-angiogenic activity, and is being investigated for anti-tumour effects and utility to treat ocular neovascularisation.

vorolanib is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 97.54
Molecular weight 439.2
XLogP 1.85
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES Fc1ccc2c(c1)/C(=C/c1[nH]c(c(c1C)C(=O)N[C@H]1CCN(C1)C(=O)N(C)C)C)/C(=O)N2
Isomeric SMILES Fc1ccc2c(c1)/C(=C/c1[nH]c(c(c1C)C(=O)N[C@H]1CCN(C1)C(=O)N(C)C)C)/C(=O)N2
InChI InChI=1S/C23H26FN5O3/c1-12-19(10-17-16-9-14(24)5-6-18(16)27-21(17)30)25-13(2)20(12)22(31)26-15-7-8-29(11-15)23(32)28(3)4/h5-6,9-10,15,25H,7-8,11H2,1-4H3,(H,26,31)(H,27,30)/b17-10-/t15-/m0/s1
InChI Key KMIOJWCYOHBUJS-HAKPAVFJSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
N-[(3S)-1-(dimethylcarbamoyl)pyrrolidin-3-yl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
International Nonproprietary Names Click here for help
INN number INN
10338 vorolanib
Synonyms Click here for help
CM-082 | CM082 | Example 8 [WO2008033562A2] | EYP-1901 | X-82
Database Links Click here for help
CAS Registry No. 1013920-15-4 (source: WHO INN record)
ChEMBL Ligand CHEMBL4297587
DrugBank Ligand DB15247
GtoPdb PubChem SID 442878652
PubChem CID 59215954
Search Google for chemical match using the InChIKey KMIOJWCYOHBUJS-HAKPAVFJSA-N
Search Google for chemicals with the same backbone KMIOJWCYOHBUJS
Search PubMed clinical trials vorolanib
Search PubMed titles vorolanib
Search PubMed titles/abstracts vorolanib
UniChem Compound Search for chemical match using the InChIKey KMIOJWCYOHBUJS-HAKPAVFJSA-N
UniChem Connectivity Search for chemical match using the InChIKey KMIOJWCYOHBUJS-HAKPAVFJSA-N

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Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.

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MedChemExpress
Vorolanib (links to external site)
Cat. No. HY-109019
(Same CID)