WAY-255348 [Ligand Id: 8664] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL407848 (WAY-255348) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275] | ||||||||
| ChEMBL | Antagonist activity at human AR ligand binding domain expressed in african green monkey COS7 cells in presence of 5-alpha-dihydrotestosterone by Gal4 hybrid assay | B | 6.71 | pIC50 | 196 | nM | IC50 | J Med Chem (2008) 51: 1861-1873 [PMID:18318463] |
| Mineralocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1994] [GtoPdb: 626] [UniProtKB: P08235] | ||||||||
| ChEMBL | Antagonist activity at human MR ligand binding domain expressed in african green monkey COS7 cells in presence of aldosterone by Gal4 hybrid assay | B | 5.43 | pIC50 | 3700 | nM | IC50 | J Med Chem (2008) 51: 1861-1873 [PMID:18318463] |
| Progesterone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401] | ||||||||
| ChEMBL | Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase | F | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2008) 51: 1861-1873 [PMID:18318463] |
| ChEMBL | Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assay | B | 8.39 | pIC50 | 4.1 | nM | IC50 | J Med Chem (2008) 51: 1861-1873 [PMID:18318463] |
| GtoPdb | - | - | 8.39 | pIC50 | 4.1 | nM | IC50 |
J Med Chem (2008) 51: 1861-73 [PMID:18318463]; Biochem Pharmacol (2011) 82: 1709-19 [PMID:21854761] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
