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ChEMBL ligand: CHEMBL379300 (A-443654, A-4436554) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
ChEMBL | Inhibition of Akt1 in presence of 10 uM ATP | B | 9.8 | pKi | 0.16 | nM | Ki | Bioorg. Med. Chem. Lett. (2006) 16: 3740-3744 [PMID:16678413] |
ChEMBL | Inhibition of AKT1 | B | 9.8 | pKi | 0.16 | nM | Ki | Nat. Chem. Biol. (2009) 5: 484-493 [PMID:19465931] |
GtoPdb | - | - | 9.8 | pKi | 0.16 | nM | Ki | Mol Cancer Ther (2005) 4: 977-86 [PMID:15956255] |
ChEMBL | Inhibition of myristoylated wild type AKT1 expressed in HEK293T cells by in vitro immunoprecipitation kinase assay | B | 8.6 | pIC50 | 2.5 | nM | IC50 | Nat. Chem. Biol. (2009) 5: 484-493 [PMID:19465931] |
ChEMBL | Inhibition of human Akt1 | B | 9.8 | pIC50 | 0.16 | nM | IC50 | J. Med. Chem. (2007) 50: 2990-3003 [PMID:17523610] |
ChEMBL | Inhibition of Akt | B | 9.8 | pIC50 | 0.16 | nM | IC50 | Eur. J. Med. Chem. (2009) 44: 4090-4097 [PMID:19497644] |
AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751] | ||||||||
GtoPdb | - | - | 9.8 | pKi | ~0.16 | nM | Ki | Mol Cancer Ther (2005) 4: 977-86 [PMID:15956255] |
ChEMBL | Inhibition of myristoylated wild type AKT2 expressed in HEK293T cells by in vitro immunoprecipitation kinase assay | B | 7.52 | pIC50 | 30 | nM | IC50 | Nat. Chem. Biol. (2009) 5: 484-493 [PMID:19465931] |
AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243] | ||||||||
GtoPdb | - | - | 9.8 | pKi | ~0.16 | nM | Ki | Mol Cancer Ther (2005) 4: 977-86 [PMID:15956255] |
ChEMBL | Inhibition of myristoylated wild type AKT3 expressed in HEK293T cells by in vitro immunoprecipitation kinase assay | B | 7.29 | pIC50 | 51 | nM | IC50 | Nat. Chem. Biol. (2009) 5: 484-493 [PMID:19465931] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]