lidorestat [Ligand Id: 7411] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL363387 (EML 676, EML-676, IDD-000676, IDD-000676-01, IDD 676, IDD-676, Lidorestat, Lidorestat anhydrous, Lindolrestat, Lindorestat) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Aldehyde reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2246] [UniProtKB: P14550] | ||||||||
| ChEMBL | In vitro inhibition of recombinant human aldehyde reductase | B | 4.57 | pIC50 | 27000 | nM | IC50 | J Med Chem (2005) 48: 3141-3152 [PMID:15857120] |
| aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] | ||||||||
| ChEMBL | Inhibition of human recombinant aldose reductase 1 after 10 mins by spectrophotometry analysis | B | 4.57 | pIC50 | 27000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2006-2008 [PMID:19250825] |
| GtoPdb | In vitro inhibition of recombinant human aldose reductase expressed in E coli. | - | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2005) 48: 3141-52 [PMID:15857120] |
| ChEMBL | In vitro inhibition of recombinant human aldose reductase expressed in Escherichia coli | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2005) 48: 3141-3152 [PMID:15857120] |
| ChEMBL | Inhibition of aldose reductase | B | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem (2007) 15: 7865-7877 [PMID:17870536] |
| aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] | ||||||||
| ChEMBL | Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometry | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2015) 58: 2649-2657 [PMID:25695864] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
