GtoPdb Ligand ID: 9589

Synonyms: MGA-271 | MGA271
Compound class: Antibody
Comment: Enoblituzumab (MGA271) is a humanized IgG1κ mAb with enhanced ADCC. Its target is the B7-H3 (CD276) member of the B7 family of immune regulators [2]. It has been engineered to enhance effector-mediated antitumor function via increased affinity for the activating receptor CD16A (FcγRIII) and decreased binding to the inhibitory receptor CD32B (FcγRIIB).
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
BLAST sequence analysis identifies exact matches with antibody peptides claimed in patent US8802091, and specifically with a construct designated as hBRCA84D-2 [1].
Compound class Antibody
International Nonproprietary Names
INN number INN
10165 enoblituzumab
MGA-271 | MGA271
Database Links
Specialist databases
IMGT/mAb-DB 590
Other databases
GtoPdb PubChem SID 340590220
Search PubMed clinical trials enoblituzumab
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