enoblituzumab   Click here for help

GtoPdb Ligand ID: 9589

Synonyms: MGA-271 | MGA271
Immunopharmacology Ligand
Compound class: Antibody
Comment: Enoblituzumab (MGA271) is a humanized IgG1κ mAb with enhanced ADCC. Its target is the B7-H3 (CD276) member of the B7 family of immune regulators [2]. It has been engineered to enhance effector-mediated antitumor function via increased affinity for the activating receptor CD16A (FcγRIII) and decreased binding to the inhibitory receptor CD32B (FcγRIIB).
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
BLAST sequence analysis identifies exact matches with antibody peptides claimed in patent US8802091, and specifically with a construct designated as hBRCA84D-2 [1].
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Bioactivity Comments
Enoblituzumab has potent antitumour activity in B7-H3-expressing cancers, which is mediated by potent ADCC [2].
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
B7-H3 (CD276) Monkey Antibody Binding 7.7 pKd - 2
pKd 7.7 (Kd 2.25x10-8 M) [2]
Description: By surface plasmon resonance (SPR) assay.
B7-H3 (CD276) Primary target of this compound Hs Antibody Binding 7.6 pKd - 2
pKd 7.6 (Kd 2.45x10-8 M) [2]
Description: By surface plasmon resonance (SPR) assay