clenbuterol [Ligand Id: 12582] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL49080 (Clenbuterol, Clenbuterol hydrochloride, Contraspasmin, NAB 365, NSC-758633, Planipart, Spiropent, Spiropent mite) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| ChEMBL | DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) | B | 7.16 | pKi | 69 | nM | Ki | DrugMatrix in vitro pharmacology data |
| GtoPdb | - | - | 7.9 | pKi | - | - | - |
Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599]; Mol Pharmacol (2015) 87: 103-20 [PMID:25324048] |
| ChEMBL | DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) | B | 6.92 | pIC50 | 120 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| GtoPdb | - | - | 9.2 | pEC50 | - | - | - | Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599] |
| β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
| ChEMBL | Binding affinity to beta-2 adrenergic receptor (unknown origin) at 1 to 10000 nM | B | 7.8 | pKd | 15.85 | nM | Kd | Bioorg Med Chem Lett (2013) 23: 5376-5381 [PMID:23954364] |
| ChEMBL | Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting | B | 6.24 | pKi | 570 | nM | Ki | J Med Chem (2009) 52: 1773-1777 [PMID:19245211] |
| ChEMBL | DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) | B | 7.55 | pKi | 28 | nM | Ki | DrugMatrix in vitro pharmacology data |
| GtoPdb | - | - | 7.9 | pKi | - | - | - |
Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599]; J Med Chem (2009) 52: 1773-7 [PMID:19245211]; Mol Pharmacol (2015) 87: 103-20 [PMID:25324048] |
| ChEMBL | Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting | B | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (2009) 52: 1773-1777 [PMID:19245211] |
| ChEMBL | DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) | B | 7.39 | pIC50 | 41 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| GtoPdb | - | - | 9.2 | pEC50 | - | - | - | Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599] |
| Beta-2 adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3373] [UniProtKB: Q28044] | ||||||||
| ChEMBL | Apparent binding affinity constant to beta-2 adrenergic receptor determined using [3H]DHA | B | 7.43 | pKd | 0.04 | uM | KD app | J Med Chem (1986) 29: 549-554 [PMID:2870189] |
| ChEMBL | Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA) | B | 7.44 | pKd | 36 | nM | Kd | J Med Chem (1985) 28: 1328-1334 [PMID:2993621] |
| ChEMBL | Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA) | B | 7.74 | pKd | 7.74 | - | -Log KD | J Med Chem (1985) 28: 1328-1334 [PMID:2993621] |
| Beta-2 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4] | ||||||||
| ChEMBL | Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as relaxation of carbachol-induced tissue contraction | F | 7.89 | pEC50 | 13 | nM | EC50 | J Med Chem (2009) 52: 1773-1777 [PMID:19245211] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
| ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) | B | 5.82 | pKi | 1515 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) | B | 5.58 | pIC50 | 2652 | nM | IC50 | DrugMatrix in vitro pharmacology data |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
