fezolinetant   Click here for help

GtoPdb Ligand ID: 10422

Synonyms: compound 3 [PMID:26191358] | ESN-364 | ESN364 | Veozah®
Approved drug
fezolinetant is an approved drug (FDA (2023))
Compound class: Synthetic organic
Comment: Fezolinetant (ESN364) is a potent and selective neurokinin (NK) receptor 3 antagonist [3]. It was developed by Astellas Pharma as a non-hormonal therapeutic option for the treatment of sex-hormone disorders such as polycystic ovary syndrome [2] and uterine fibroids, and for the management of the vasomotor symptoms (VMS) that drive menopausal hot flashes/flushes and/or night sweats [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 105.04
Molecular weight 358.1
XLogP 4.12
No. Lipinski's rules broken 0
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Canonical SMILES Fc1ccc(cc1)C(=O)N1CCn2c(C1C)nnc2c1snc(n1)C
Isomeric SMILES Fc1ccc(cc1)C(=O)N1CCn2c([C@H]1C)nnc2c1snc(n1)C
InChI InChI=1S/C16H15FN6OS/c1-9-13-19-20-14(15-18-10(2)21-25-15)23(13)8-7-22(9)16(24)11-3-5-12(17)6-4-11/h3-6,9H,7-8H2,1-2H3/t9-/m1/s1
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2023))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
10205 fezolinetant
Synonyms Click here for help
compound 3 [PMID:26191358] | ESN-364 | ESN364 | Veozah®
Database Links Click here for help
Specialist databases
GPCRdb Ligand fezolinetant
Other databases
CAS Registry No. 1629229-37-3 (source: WHO INN record)
ChEMBL Ligand CHEMBL3608680
GtoPdb PubChem SID 385612182
PubChem CID 117604931
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UniChem Compound Search for chemical match using the InChIKey PPSNFPASKFYPMN-SECBINFHSA-N
UniChem Connectivity Search for chemical match using the InChIKey PPSNFPASKFYPMN-SECBINFHSA-N