ChEMBL ligand: CHEMBL430266
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] There should be some charts here, you may need to enable JavaScript!
Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform in Human [ChEMBL: CHEMBL4763] [UniProtKB: Q15172] There should be some charts here, you may need to enable JavaScript!
Serine-threonine protein phosphatase 2A regulatory subunit in Chicken [ChEMBL: CHEMBL2669] [UniProtKB: Q8AWE3] There should be some charts here, you may need to enable JavaScript!
Serine/threonine protein phosphatase PP1-gamma catalytic subunit in Human [ChEMBL: CHEMBL4438] [UniProtKB: P36873] There should be some charts here, you may need to enable JavaScript!
protein phosphatase 2 catalytic subunit alpha in Human [GtoPdb: 3263] [UniProtKB: P67775] There should be some charts here, you may need to enable JavaScript!
protein phosphatase 1 catalytic subunit alpha in Human [GtoPdb: 3264] [UniProtKB: P62136] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
ChEMBL	Observed inhibition activity of the compounds against protein phosphatases 1 (PP1)	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (1997) 40: 3199-3206 [PMID:9379439]
ChEMBL	Inhibitory concentration against Protein phosphatase 1 was determined; 0.5-1.0	B	9.3	pIC50	0.5	nM	IC50	Bioorg Med Chem Lett (2002) 12: 391-393 [PMID:11814804]
ChEMBL	Tested for inhibition against purified catalytic subunit of protein phosphatase-1 from rabbit skeletal muscle	B	9.52	pIC50	0.3	nM	IC50	Bioorg Med Chem Lett (1993) 3: 1029-1034
Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4763] [UniProtKB: Q15172]
ChEMBL	Tested for inhibition of purified catalytic subunit of protein phosphatase-2A from human erythrocytes	B	9.89	pIC50	0.13	nM	IC50	Bioorg Med Chem Lett (1993) 3: 1029-1034
Serine-threonine protein phosphatase 2A regulatory subunit in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2669] [UniProtKB: Q8AWE3]
ChEMBL	Observed inhibition activity of the compounds against protein phosphatases 2A (PP2A)	B	8.14	pIC50	7.3	nM	IC50	J Med Chem (1997) 40: 3199-3206 [PMID:9379439]
ChEMBL	Concentration required to inhibit the action of protein phosphatase 2A	B	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2002) 12: 391-393 [PMID:11814804]
ChEMBL	Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)	B	9.7	pIC50	0.2	nM	IC50	J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
Serine/threonine protein phosphatase PP1-gamma catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4438] [UniProtKB: P36873]
ChEMBL	Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in R221S	B	6.3	pIC50	>500	nM	IC50	J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL	Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in N124D	B	6.3	pIC50	>500	nM	IC50	J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL	Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in H248N	B	6.3	pIC50	>500	nM	IC50	J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL	Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in D208A	B	6.3	pIC50	>500	nM	IC50	J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL	Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in R96A	B	7.24	pIC50	58	nM	IC50	J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL	Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in Y272F	B	7.32	pIC50	48	nM	IC50	J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL	Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in C127S	B	8.66	pIC50	2.2	nM	IC50	J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL	Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in wild type	B	9.35	pIC50	0.45	nM	IC50	J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL	Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in E275R	B	9.4	pIC50	0.4	nM	IC50	J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
ChEMBL	Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in D220V	B	9.85	pIC50	0.14	nM	IC50	J Med Chem (2002) 45: 1151-1175 [PMID:11881984]
protein phosphatase 2 catalytic subunit alpha in Human [GtoPdb: 3263] [UniProtKB: P67775]
GtoPdb	-	-	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2002) 12: 391-3 [PMID:11814804]
protein phosphatase 1 catalytic subunit alpha in Human [GtoPdb: 3264] [UniProtKB: P62136]
GtoPdb	-	-	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2002) 12: 391-3 [PMID:11814804]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]