nisoxetine [Ligand Id: 4637] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL295467 (COMPOUND 89218, LY-94939, Nisoxetine, NSC-283481) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] | ||||||||
| ChEMBL | Binding affinity for dopamine transporter expressed in LCK PK1 cells | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2004) 47: 5258-5264 [PMID:15456270] |
| ChEMBL | In vitro competitive binding versus [N-methyl-3H]WIN-35428 in murine kidney cells transfected with cDNA for human dopamine transporter (DAT) | B | 7.52 | pKi | 30 | nM | Ki | J Med Chem (2003) 46: 925-935 [PMID:12620070] |
| ChEMBL | Inhibition of dopamine uptake at human DAT expressed in HEK cells | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4495-4498 [PMID:18667309] |
| ChEMBL | Inhibition of dopamine uptake at human DAT in human HEK293 cells | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4224-4227 [PMID:18550369] |
| ChEMBL | Inhibition of human DAT expressed in HEK293 cells assessed as inhibition of dopamine reuptake after 30 mins by fluorescence assay | B | 5.94 | pIC50 | 1150 | nM | IC50 | J Med Chem (2012) 55: 8188-8192 [PMID:22938049] |
| ChEMBL | Inhibition of DA reuptake at human DAT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay | B | 5.94 | pIC50 | 1150 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3234-3237 [PMID:24974340] |
| ChEMBL | Inhibition of human DAT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay | B | 5.94 | pIC50 | 1150 | nM | IC50 | ACS Med Chem Lett (2014) 5: 999-1004 [PMID:25221656] |
| DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977] | ||||||||
| ChEMBL | Binding affinity against dopamine transporter (DAT) by displacement of [3H]WIN-35428 in male wistar rats | B | 6.3 | pIC50 | >500 | nM | IC50 | J Med Chem (2003) 46: 5512-5532 [PMID:14640559] |
| NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] | ||||||||
| ChEMBL | Inhibition of norepinephrine reuptake at NET | B | 8.22 | pKi | 6 | nM | Ki | Bioorg Med Chem (2009) 17: 7802-7815 [PMID:19836247] |
| GtoPdb | - | - | 8.4 | pKi | 3.98 | nM | Ki | |
| ChEMBL | Binding affinity for Norepinephrine transporter (NET) expressed in LCK PK1 cells | B | 8.8 | pKi | 1.6 | nM | Ki | J Med Chem (2004) 47: 5258-5264 [PMID:15456270] |
| ChEMBL | Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3234-3237 [PMID:24974340] |
| ChEMBL | Inhibition of human NET expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay | B | 7.7 | pIC50 | 20 | nM | IC50 | ACS Med Chem Lett (2014) 5: 999-1004 [PMID:25221656] |
| ChEMBL | Inhibition of human NET expressed in HEK293 cells assessed as inhibition of noradrenaline reuptake after 30 mins by fluorescence assay | B | 7.74 | pIC50 | 18 | nM | IC50 | J Med Chem (2012) 55: 8188-8192 [PMID:22938049] |
| ChEMBL | Inhibition of norepinephrine uptake at human NET expressed in HEK cells | B | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4495-4498 [PMID:18667309] |
| ChEMBL | Inhibition of norepinephrine uptake at human NET in human HEK293 cells | B | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4224-4227 [PMID:18550369] |
| ChEMBL | Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation counting | B | 8.08 | pIC50 | 8.3 | nM | IC50 | Bioorg Med Chem (2011) 19: 663-676 [PMID:21093273] |
| ChEMBL | Inhibition of norepinephrine reuptake at NET expressed in MDCK cells | B | 8.1 | pIC50 | 7.94 | nM | IC50 | J Med Chem (2011) 54: 5283-5295 [PMID:21739935] |
| ChEMBL | Inhibition of [3H]norepinephrine reuptake at human recombinant NET expressed in HEK293 cells by scintillation counting | B | 8.1 | pIC50 | 7.94 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 1434-1437 [PMID:21310612] |
| ChEMBL | Inhibition of norepinephrine uptake at human NET expressed in MDCK cells | B | 8.22 | pIC50 | 6 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4929-4931 [PMID:18771916] |
| ChEMBL | Inhibition of human NET expressed in COS7 cells assessed as inhibition of [3H]norepinephrine uptake | B | 8.99 | pEC50 | -8.99 | - | logEC50 | J Med Chem (2009) 52: 6991-7002 [PMID:19860431] |
| Norepinephrine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4] | ||||||||
| ChEMBL | Binding affinity against norepinephrine transporter (NET) by displacement of [3H]nisoxetine in male wistar rats | B | 8 | pKi | 9.9 | nM | Ki | J Med Chem (2003) 46: 5512-5532 [PMID:14640559] |
| ChEMBL | Displacement of [3H]-nisoxetine from NET in Sprague-Dawley rat brain prefrontal cortex incubated for 180 mins by radioligand binding assay | B | 8.82 | pKi | 1.5 | nM | Ki | RSC Med Chem (2021) 12: 1174-1186 [PMID:34355183] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
| ChEMBL | Binding affinity against 5-hydroxytryptamine 1A receptor (5-HT1A) by displacement of [3H]8-OH-DPAT from rat hippocampus membranes | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2003) 46: 5512-5532 [PMID:14640559] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] | ||||||||
| ChEMBL | Binding affinity against 5-hydroxytryptamine 2A receptor by displacement of [3H]-ketanserin from rat prefrontal cerebral cortex mambranes | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2003) 46: 5512-5532 [PMID:14640559] |
| SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] | ||||||||
| ChEMBL | Binding affinity for serotonin transporter expressed in LCK PK1 cells | B | 6.69 | pKi | 203 | nM | Ki | J Med Chem (2004) 47: 5258-5264 [PMID:15456270] |
| ChEMBL | In vitro competitive binding versus [3H]-citalopram in murine kidney cells transfected with cDNA for human serotonin transporter (SERT) | B | 8.85 | pKi | 1.4 | nM | Ki | J Med Chem (2003) 46: 925-935 [PMID:12620070] |
| ChEMBL | Inhibition of serotonin uptake at human SERT expressed in HEK cells | B | 5.85 | pIC50 | 1400 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4495-4498 [PMID:18667309] |
| ChEMBL | Inhibition of serotonin uptake at human SERT in human HEK293 cells | B | 5.85 | pIC50 | 1400 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4224-4227 [PMID:18550369] |
| ChEMBL | Inhibition of human SERT expressed in HEK293 cells assessed as inhibition of serotonin reuptake after 30 mins by fluorescence assay | B | 6.15 | pIC50 | 700 | nM | IC50 | J Med Chem (2012) 55: 8188-8192 [PMID:22938049] |
| ChEMBL | Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay | B | 6.15 | pIC50 | 700 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3234-3237 [PMID:24974340] |
| ChEMBL | Inhibition of human SERT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay | B | 6.15 | pIC50 | 700 | nM | IC50 | ACS Med Chem Lett (2014) 5: 999-1004 [PMID:25221656] |
| ChEMBL | Inhibition of serotonin uptake at human SERT expressed in JAR cells | B | 6.56 | pIC50 | 277 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4929-4931 [PMID:18771916] |
| SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] | ||||||||
| ChEMBL | Displacement of [3H]citalopram from SERT in Sprague-dawley rat frontal cortex by liquid scintillation spectrophotometry | B | 6.56 | pKi | 277 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 58-61 [PMID:19038547] |
| ChEMBL | Binding affinity against serotonin transporter (SERT) by displacement of [3H]paroxetine in male wistar rats | B | 6.3 | pIC50 | >500 | nM | IC50 | J Med Chem (2003) 46: 5512-5532 [PMID:14640559] |
| Transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6184] [UniProtKB: Q63380] | ||||||||
| ChEMBL | Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometry | B | 8.22 | pKi | 6 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 58-61 [PMID:19038547] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
