ceftriaxone [Ligand Id: 5326] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL161 (Ceftriaxon, Ceftriaxone)
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  • Organic anion transporter 4/Solute carrier family 22 member 11 in Human [ChEMBL: CHEMBL2073677] [GtoPdb: 1030] [UniProtKB: Q9NSA0]
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  • Organic anion transporter 1/Solute carrier family 22 member 6 in Human [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8]
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  • Organic anion transporter 3/Solute carrier family 22 member 8 in Human [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [UniProtKB: P37840]
ChEMBL Binding affinity to alpha-synuclein (unknown origin) expressed in Escherichia coli BL21(DE3) by circular dichroism analysis B 6.28 pKd 530 nM Kd Eur J Med Chem (2019) 167: 10-36 [PMID:30743095]
D-amino-acid oxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5485] [UniProtKB: P14920]
ChEMBL Inhibition of DAAO (unknown origin) B 5 pIC50 10000 nM IC50 J Med Chem (2015) 58: 7258-7272 [PMID:26309148]
Organic anion transporter 4/Solute carrier family 22 member 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073677] [GtoPdb: 1030] [UniProtKB: Q9NSA0]
ChEMBL TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT4-expressing S2 cells F 5.62 pKi 2380 nM Ki Eur J Pharmacol (2002) 438: 137-142 [PMID:11909604]
Organic anion transporter 1/Solute carrier family 22 member 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8]
ChEMBL TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells F 6.64 pKi 230 nM Ki Eur J Pharmacol (2002) 438: 137-142 [PMID:11909604]
Organic anion transporter 3/Solute carrier family 22 member 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7]
ChEMBL TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells F 5.36 pKi 4390 nM Ki Eur J Pharmacol (2002) 438: 137-142 [PMID:11909604]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]